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blind injection of Triamcinolone
Triamcinolone is a synthetic corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors.
Triamcinolone is a synthetic corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors. Used for Intra-articular injection for inflammatory joint conditions and arthritis, Periarticular injection for soft tissue inflammation and pain.
At a glance
| Generic name | blind injection of Triamcinolone |
|---|---|
| Also known as | Blind introduction of Triamcinolone |
| Sponsor | Complejo Hospitalario Universitario de Granada |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Rheumatology / Orthopedics / Immunology |
| Phase | FDA-approved |
Mechanism of action
Triamcinolone exerts its anti-inflammatory effects by translocating to the nucleus and modulating gene expression of pro-inflammatory cytokines, adhesion molecules, and immune mediators. When administered via blind injection (typically intra-articular or periarticular), it provides localized immunosuppression and reduces inflammation at the injection site, with systemic absorption being minimal.
Approved indications
- Intra-articular injection for inflammatory joint conditions and arthritis
- Periarticular injection for soft tissue inflammation and pain
Common side effects
- Local injection site reaction
- Transient increase in joint pain (post-injection flare)
- Infection at injection site
- Systemic corticosteroid effects (with repeated injections)
Key clinical trials
- Corticosteroid Against Saline Injections for Thumb Osteoarthritis (CASITOA) (PHASE2)
- Efficacy of Ultrasound-Guided Genicular Nerve Block in Patients With Gonarthrosis: A Randomized, Placebo-Controlled, Double-Blind Study (NA)
- Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis (PHASE2)
- Ketorolac in Upper Extremity Tendinopathy and Arthropathy (PHASE4)
- Ecoguided Genicular Nerve Block (NA)
- The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis (PHASE4)
- Multimodal Nerve Block and Pulse Radiofrequency for Acute Herpes Zoster Pain (NA)
- Photobiomodulation and the Intralesional Administration of Corticoid in the Keloid Surgery. (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |