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Bleaching Agents
Bleaching agents work by oxidizing or chemically altering pigmented molecules in skin to lighten hyperpigmented areas or remove discoloration.
Bleaching agents work by oxidizing or chemically altering pigmented molecules in skin to lighten hyperpigmented areas or remove discoloration. Used for Hyperpigmentation and melasma, Post-inflammatory hyperpigmentation, Age spots and solar lentigines.
At a glance
| Generic name | Bleaching Agents |
|---|---|
| Sponsor | André Luis Faria e Silva |
| Drug class | Topical depigmenting agent |
| Target | Tyrosinase (primary); melanin (direct oxidation) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Bleaching agents typically contain active ingredients such as hydroquinone, kojic acid, or hydrogen peroxide that inhibit melanin synthesis or promote melanin degradation through oxidative processes. These agents are applied topically to reduce the appearance of dark spots, melasma, post-inflammatory hyperpigmentation, and other forms of skin discoloration by suppressing tyrosinase activity or directly bleaching existing pigment.
Approved indications
- Hyperpigmentation and melasma
- Post-inflammatory hyperpigmentation
- Age spots and solar lentigines
Common side effects
- Contact dermatitis
- Skin irritation
- Erythema
- Exogenous ochronosis (with prolonged use)
Key clinical trials
- Effect of Bleaching Regimen With Different Activation Modes on Color Stability, Surface Roughness, Tooth Sensitivity and Patient Satisfaction (NA)
- Bioadhesive Film of Acmella Oleracea (Jambu) in the Reduction of Post-bleaching Dental Sensitivity Caused by Bleaching With 35% Hydrogen Peroxide. (PHASE3)
- Combination of Oral and Topical Whitening Agents for Reducing Skin Pigmentation (NA)
- Effect of Whitening Agent With Emulsion Gel in Saliva and Halitosis (NA)
- Efficacy of a Desensitizing Agent During In-Office Bleaching (EARLY_PHASE1)
- The Influence of Isolation Techniques in Gingival Irritation During an In-office Bleaching (NA)
- Clinical Evaluation of Enamel Microhardness Using Tooth Whitening Agents (NA)
- A Comparative Study Between the Efficacy of Diode Laser and Nano-chitosan Gel on Activation of Non-vital in- Office Bleaching Agent (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bleaching Agents CI brief — competitive landscape report
- Bleaching Agents updates RSS · CI watch RSS
- André Luis Faria e Silva portfolio CI