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Bioseal Fibrin Sealant

Ethicon, Inc. · FDA-approved active Biologic

Bioseal Fibrin Sealant is a Fibrin sealant / Hemostatic agent Biologic drug developed by Ethicon, Inc.. It is currently FDA-approved for Hemostasis and tissue sealing during general surgery, Hemostasis during cardiovascular surgery, Hemostasis during orthopedic surgery.

Bioseal Fibrin Sealant is a topical hemostatic agent that forms a fibrin clot to seal tissue surfaces and control bleeding during surgery.

Bioseal Fibrin Sealant is a topical hemostatic agent that forms a fibrin clot to seal tissue surfaces and control bleeding during surgery. Used for Hemostasis and tissue sealing during general surgery, Hemostasis during cardiovascular surgery, Hemostasis during orthopedic surgery.

At a glance

Generic nameBioseal Fibrin Sealant
SponsorEthicon, Inc.
Drug classFibrin sealant / Hemostatic agent
ModalityBiologic
Therapeutic areaSurgery / Hemostasis
PhaseFDA-approved

Mechanism of action

The product combines human fibrinogen and human thrombin to create a fibrin clot at the site of application, providing hemostasis and tissue sealing. When the two components mix, thrombin converts fibrinogen to fibrin, which polymerizes to form a stable clot that adheres to tissue surfaces. This mechanical seal helps control bleeding and can be absorbed by the body over time.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Bioseal Fibrin Sealant

What is Bioseal Fibrin Sealant?

Bioseal Fibrin Sealant is a Fibrin sealant / Hemostatic agent drug developed by Ethicon, Inc., indicated for Hemostasis and tissue sealing during general surgery, Hemostasis during cardiovascular surgery, Hemostasis during orthopedic surgery.

How does Bioseal Fibrin Sealant work?

Bioseal Fibrin Sealant is a topical hemostatic agent that forms a fibrin clot to seal tissue surfaces and control bleeding during surgery.

What is Bioseal Fibrin Sealant used for?

Bioseal Fibrin Sealant is indicated for Hemostasis and tissue sealing during general surgery, Hemostasis during cardiovascular surgery, Hemostasis during orthopedic surgery.

Who makes Bioseal Fibrin Sealant?

Bioseal Fibrin Sealant is developed and marketed by Ethicon, Inc. (see full Ethicon, Inc. pipeline at /company/ethicon-inc).

What drug class is Bioseal Fibrin Sealant in?

Bioseal Fibrin Sealant belongs to the Fibrin sealant / Hemostatic agent class. See all Fibrin sealant / Hemostatic agent drugs at /class/fibrin-sealant-hemostatic-agent.

What development phase is Bioseal Fibrin Sealant in?

Bioseal Fibrin Sealant is FDA-approved (marketed).

What are the side effects of Bioseal Fibrin Sealant?

Common side effects of Bioseal Fibrin Sealant include Infection at surgical site, Seroma formation, Allergic reaction, Thromboembolism (rare).

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