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Biological mesh
Biological mesh provides structural support and promotes tissue integration through naturally-derived or bioengineered extracellular matrix material.
Biological mesh provides structural support and promotes tissue integration through naturally-derived or bioengineered extracellular matrix material. Used for Hernia repair (ventral, incisional, or abdominal wall reconstruction), Soft tissue reinforcement and regeneration.
At a glance
| Generic name | Biological mesh |
|---|---|
| Also known as | Biologics, Acellular dermal matrix |
| Sponsor | University Hospital, Lille |
| Drug class | Biological scaffold/tissue engineering product |
| Modality | Biologic |
| Therapeutic area | Surgery/Tissue Repair |
| Phase | Phase 3 |
Mechanism of action
Biological meshes are scaffolds composed of decellularized or processed biological tissue (often derived from animal sources such as porcine or bovine materials, or human cadaveric tissue) that serve as a framework for tissue regeneration and repair. They are designed to be gradually resorbed and replaced by the patient's own tissue, providing mechanical support while facilitating vascularization and cellular infiltration at the surgical site.
Approved indications
- Hernia repair (ventral, incisional, or abdominal wall reconstruction)
- Soft tissue reinforcement and regeneration
Common side effects
- Seroma formation
- Infection
- Mesh rejection or inflammatory response
- Recurrent hernia
Key clinical trials
- SIS-Reinforced vs. Conventional Anastomosis for Mid-to-Low Rectal Cancer: A Multicenter RCT on Anastomotic Leak (PHASE4)
- Stoma Closure and Reinforcement Trial ll (NA)
- Regenerative Treatment of Peri-implantitis (NA)
- Study on the Cosmetic Outcome and Safety Evaluation of 3D Printed Biodegradable Biological Mesh for One-Stage Breast Reconstruction After Radical Mastectomy (NA)
- Early Clinical Outcomes of High-Purity Type I Collagen as a Biologic Reinforcement in Selected Hernia Repair Scenarios (NA)
- High-Purity Type I Collagen Augmentation in Meniscal Repair (NA)
- Biological OviTex Versus Synthetic Graft in Robotic Prolapse Surgery (NA)
- Biological Meshes in Infected Fields: a Randomized Controlled Trial (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Biological mesh CI brief — competitive landscape report
- Biological mesh updates RSS · CI watch RSS
- University Hospital, Lille portfolio CI