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Bioactive glass
Bioactive glass promotes bone regeneration and healing by releasing bioactive ions that stimulate osteoblast activity and mineralization at the implant site.
Bioactive glass promotes bone regeneration and healing by releasing bioactive ions that stimulate osteoblast activity and mineralization at the implant site. Used for Bone defect repair and regeneration, Dental and maxillofacial applications.
At a glance
| Generic name | Bioactive glass |
|---|---|
| Also known as | Sylc, Novabone |
| Sponsor | King Abdulaziz University |
| Drug class | Bioactive ceramic material |
| Modality | Small molecule |
| Therapeutic area | Orthopedics / Regenerative Medicine |
| Phase | Phase 3 |
Mechanism of action
Bioactive glass is a silica-based ceramic material that forms a chemical bond with bone tissue through a series of surface reactions. When implanted, it releases calcium, phosphate, and silica ions that create an apatite layer on the glass surface, which mimics the mineral phase of bone and promotes new bone formation. This material also exhibits antimicrobial properties and can modulate inflammatory responses to support tissue regeneration.
Approved indications
- Bone defect repair and regeneration
- Dental and maxillofacial applications
Common side effects
- Inflammation at implant site
- Delayed healing
- Material degradation
Key clinical trials
- Clinical Outcomes of Bioactive Glass S53P4 in Radical Mastoid Cavity Obliteration
- XVIE to Treat Androgenetic Alopecia (AGA) (PHASE1, PHASE2)
- Assessment of Alkasite Restorative Material Versus Resin Modified Glass Ionomer in Class V Cavities: A Clinical Trial (NA)
- Clinical Performance of a Novel Self-cured Resin Composite Compared to a Light-cured Bioactive Resin Composite Restoration in Proximal Cavities of Posterior Teeth (EARLY_PHASE1)
- FIBERGRAFT Aeridyan Posterolateral Fusion Study (NA)
- Effect of Diode Laser and Bioactive Glass on Dentinal Hypersensitivity (NA)
- Effect of Gluma and Bioactive Glass Desensitizers in Treatment of Dentin Hypersensitivity in Cervical Non-Carious Lesions (NA)
- Retention Rate And Caries Prevention Of Giomer Based Sealant With And Without Pre-Treatment With Bioactive Glass Air Abrasion In Young Adults (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bioactive glass CI brief — competitive landscape report
- Bioactive glass updates RSS · CI watch RSS
- King Abdulaziz University portfolio CI