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Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill
Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill is a Antiretroviral combination (integrase inhibitor + nucleoside reverse transcriptase inhibitors) Small molecule drug developed by Charlotte-Paige Rolle, MD. It is currently FDA-approved for HIV-1 infection in treatment-naïve and treatment-experienced adults. Also known as: Biktarvy.
This combination pill inhibits HIV reverse transcriptase and integrase to block viral replication and prevent the virus from integrating into host cell DNA.
This combination pill inhibits HIV reverse transcriptase and integrase to block viral replication and prevent the virus from integrating into host cell DNA. Used for HIV-1 infection in treatment-naïve and treatment-experienced adults.
At a glance
| Generic name | Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill |
|---|---|
| Also known as | Biktarvy |
| Sponsor | Charlotte-Paige Rolle, MD |
| Drug class | Antiretroviral combination (integrase inhibitor + nucleoside reverse transcriptase inhibitors) |
| Target | HIV integrase, HIV reverse transcriptase |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Virology |
| Phase | FDA-approved |
Mechanism of action
Bictegravir is an integrase strand transfer inhibitor (INSTI) that prevents HIV from inserting its genetic material into human chromosomes. Emtricitabine and tenofovir alafenamide are nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) that block the enzyme responsible for converting viral RNA into DNA. Together, these three agents target multiple steps of the HIV replication cycle.
Approved indications
- HIV-1 infection in treatment-naïve and treatment-experienced adults
Common side effects
- Nausea
- Diarrhea
- Headache
- Fatigue
- Elevated creatinine
Key clinical trials
- DTG/3TC vs. BIC/FTC/TAF Maintenance Therapy in People Living With HIV: (PHASE4)
- A Study of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Evaluated as a Fixed Dose Combination Regimen in Participants Switching From an Integrase Inhibitor Who Have Experienced Rapid Weight Gain (PHASE4)
- Efficacy of Switching to DTG/3TC in Virologically-suppressed Adults Currently on B/F/TAF (PHASE4)
- Next Generation Ingestible Sensors for Medication Adherence Measurement (PHASE3)
- Efficacy, Safety & Tolerability of Switching EFV/TDF/FTC to BIC/FTC/TAF in Virologically Suppressed Adults With HIV-1 (PHASE4)
- Development of a Silica Microparticle Taggant System to Measure ART Adherence (NA)
- BFTAF Elderly Switch Study (PHASE4)
- B/F/TAF vs Atripla Double-Blind Switch Study in HIV-1 Infected Adults (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill CI brief — competitive landscape report
- Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill updates RSS · CI watch RSS
- Charlotte-Paige Rolle, MD portfolio CI
Frequently asked questions about Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill
What is Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill?
How does Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill work?
What is Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill used for?
Who makes Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill?
Is Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill also known as anything else?
What drug class is Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill in?
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What does Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill target?
Related
- Drug class: All Antiretroviral combination (integrase inhibitor + nucleoside reverse transcriptase inhibitors) drugs
- Target: All drugs targeting HIV integrase, HIV reverse transcriptase
- Manufacturer: Charlotte-Paige Rolle, MD — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Virology
- Indication: Drugs for HIV-1 infection in treatment-naïve and treatment-experienced adults
- Also known as: Biktarvy
- Compare: Bictegravir / Emtricitabine / Tenofovir Alafenamide Pill vs similar drugs
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