Last reviewed · How we verify
Betamethasone and local anesthetic
Betamethasone reduces inflammation and immune response while the local anesthetic component provides pain relief at the site of administration.
Betamethasone reduces inflammation and immune response while the local anesthetic component provides pain relief at the site of administration. Used for Inflammatory skin conditions with associated pain, Localized musculoskeletal inflammation and pain, Intra-articular or periarticular injection for joint inflammation.
At a glance
| Generic name | Betamethasone and local anesthetic |
|---|---|
| Also known as | GON block |
| Sponsor | Jakob Møller Hansen, MD. |
| Drug class | Corticosteroid with local anesthetic |
| Target | Glucocorticoid receptor (betamethasone); voltage-gated sodium channels (local anesthetic component) |
| Modality | Small molecule |
| Therapeutic area | Dermatology, Rheumatology, Pain Management |
| Phase | FDA-approved |
Mechanism of action
Betamethasone is a corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. The local anesthetic component (typically lidocaine or similar) blocks nerve conduction to provide localized pain relief. This combination is used for anti-inflammatory and analgesic effects at specific anatomical sites.
Approved indications
- Inflammatory skin conditions with associated pain
- Localized musculoskeletal inflammation and pain
- Intra-articular or periarticular injection for joint inflammation
Common side effects
- Local skin atrophy
- Local irritation or burning at injection site
- Hypopigmentation
- Systemic corticosteroid effects (with repeated use)
Key clinical trials
- Comparison of Injection Techniques in Carpal Tunnel Syndrome (PHASE4)
- "The Importance of Adding Fenestration to Ultrasound-Guided Baker's Cyst Aspiration" (NA)
- Meniscal INfiltration of Corticosteroid Guided With Ultra Sonography (PHASE3)
- Comparison of Efficacy of Betamethasone Gel With Lidocaine Gel in Prevention of Post Endotracheal Intubation Sore Throat. (PHASE1, PHASE2)
- Using a Contact Dermatitis Model With Biologic Medications to Study Skin Inflammation (PHASE2, PHASE3)
- MRI and Clinical Predictive Factors of the Response to Arthrographic Distension in Severe Capsulitis
- Analgesic Efficacy of Preemptive Stepwise Infiltration Anesthesia for Perioperative Analgesia After TKA (NA)
- Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Betamethasone and local anesthetic CI brief — competitive landscape report
- Betamethasone and local anesthetic updates RSS · CI watch RSS
- Jakob Møller Hansen, MD. portfolio CI