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Betamethasone - ACTIVE
Betamethasone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
Betamethasone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Pediatric inflammatory and autoimmune conditions, Pediatric respiratory conditions with inflammatory component.
At a glance
| Generic name | Betamethasone - ACTIVE |
|---|---|
| Also known as | antenatal corticosteroid, dexamethasone |
| Sponsor | Pediatrix |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | Phase 2 |
Mechanism of action
Betamethasone exerts its anti-inflammatory and immunosuppressive effects by entering cells and binding to cytoplasmic glucocorticoid receptors, which then translocate to the nucleus and modulate gene transcription. This leads to decreased production of inflammatory mediators such as cytokines, chemokines, and adhesion molecules, and reduces immune cell activation and migration. The drug is commonly used in pediatric populations for conditions requiring rapid anti-inflammatory or immunosuppressive action.
Approved indications
- Pediatric inflammatory and autoimmune conditions
- Pediatric respiratory conditions with inflammatory component
Common side effects
- Hyperglycemia
- Immunosuppression / increased infection risk
- Adrenal suppression
- Growth retardation (in pediatric use)
- Hypertension
- Mood changes
Key clinical trials
- Clinical Trial to Demonstrate That the Dual Laser Therapy is Effective for the Treatment of Vulvar Lichen Sclerosus (NA)
- A Study to Evaluate the Efficacy,Safety,Tolerability,Pharmacokinetics,and Immunogenicty of Plonmarlimab in Subjects With Acute Gouty Arthritis (PHASE2)
- Effect of Reparel Knee Sleeve With Knee Injection (NA)
- Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis
- Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS) (PHASE4)
- Efficacy of Corticosteroid Injection and Nerve Hydrodissection in Carpal Tunnel Syndrome (NA)
- Comparison of Laser Treatment With Clobetasol Therapy in Patients With Lichen Sclerosus (NA)
- Fractionated CO2 Laser With and Without Clobetasol for Treatment of Vulvar Lichen Sclerosus (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |