Last reviewed · How we verify
Benznidazole (BENZNIDAZOLE)
Benznidazole works by interfering with the parasite's ability to replicate and survive within the host's cells.
At a glance
| Generic name | BENZNIDAZOLE |
|---|---|
| Sponsor | Chemo Research Sl |
| Drug class | benznidazole |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
| First approval | 2017 |
Mechanism of action
Benznidazole is nitroimidazole antimicrobial drug [see Microbiology 12.4)].
Approved indications
- Chagas disease treatment
Common side effects
- Abdominal pain
- Rash
- Decreased weight
- Headache
- Nausea
- Vomiting
- Diarrhea
- Decreased appetite
- Dizziness
- Leukopenia
- Urticaria
- Eosinophilia
Drug interactions
- disulfiram
- alcohol and products containing propylene glycol
Key clinical trials
- A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease. (PHASE2)
- A Phase 1 Study of the Safety and Tolerability of ICM20 in Adults (PHASE1)
- Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age (PHASE3)
- Short Benznidazole Regimen for Chronic Phase Chagas Disease Patients (PHASE3)
- New Therapies and Biomarkers for Chagas Infection (PHASE2)
- Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease. (PHASE2)
- Shorter Benznidazole Regimens Compared to the Standard Regimen for Chagas Disease (PHASE3)
- Prospective Study of Benznidazole for Chagas' Disease Children With Chronic Indeterminate Chagas Disease (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |