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Benzathine Penicilllin G
Benzathine penicillin G inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing peptidoglycan cross-linking.
Benzathine penicillin G inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and preventing peptidoglycan cross-linking. Used for Syphilis (primary, secondary, and latent), Rheumatic fever prophylaxis, Group A Streptococcal infections.
At a glance
| Generic name | Benzathine Penicilllin G |
|---|---|
| Sponsor | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia |
| Drug class | Beta-lactam antibiotic (penicillin) |
| Target | Penicillin-binding proteins (PBPs); bacterial cell wall peptidoglycan |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Benzathine penicillin G is a long-acting formulation of penicillin that penetrates bacterial cell walls and irreversibly inhibits transpeptidase enzymes responsible for cross-linking peptidoglycan strands. This disruption of cell wall integrity leads to bacterial cell lysis and death. The benzathine salt provides sustained release, allowing for prolonged therapeutic levels and less frequent dosing compared to aqueous penicillin formulations.
Approved indications
- Syphilis (primary, secondary, and latent)
- Rheumatic fever prophylaxis
- Group A Streptococcal infections
- Acute rheumatic fever prevention
Common side effects
- Allergic reaction (rash, urticaria)
- Anaphylaxis
- Jarisch-Herxheimer reaction
- Local injection site reactions (pain, induration)
- Diarrhea
Key clinical trials
- Alternative Antibiotics for Syphilis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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