Last reviewed 2026-04-20 · How we verify

Benzododecinium (BENZALKONIUM)

Benzododecinium, also known as benzalkonium, is a small molecule drug in the benzalkonium class. It is used to treat various conditions including allergic otitis externa, itching of the ear and skin, local anesthesia, minor skin wound pain, mouth irritation, otitis externa, and post-op ocular inflammation. The commercial status of benzododecinium is not explicitly stated, but it is likely available as a generic medication. Key safety considerations include its potential for skin and eye irritation. As a local anesthetic, benzododecinium works by blocking nerve signals to numb the affected area.

At a glance

Approved indications

• Allergic otitis externa
• Itching of ear
• Itching of skin
• Local anesthesia
• Minor Skin Wound Pain
• Mouth Irritation
• Otitis externa
• Post-Op Ocular Inflammation
• Prevent Minor Bacterial Skin Infection
• Skin irritation
• Suppression of the Gag Reflex
• Uveitis

Common side effects

No common side effects on file.

Key clinical trials

• Effect of Novel Exhalational Delivery System With Fluticasone (EDS-FLU) on Eustachian Tube Dysfunction (ETD) (PHASE2)
• Nasal Decongestant to Reduce Perioperative Adverse Events in Children With Upper Respiratory Track Infections Having Anesthesia. (PHASE4)
• Hybrid Osteoplasty Versus Osteotomy in Rhinoplasty (NA)
• The Outcomes of Keystone Perforator Island Flap Versus Lay Open in Re-recurrent Pilonidal Sinus Disease (NA)
• Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis (PHASE4)
• The Effect of Antibiotic Eye Drops on the Nasal Microbiome in Healthy Subjects (PHASE2)
• Xylitol BSI Multisite - Reduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell Transplant (PHASE2)
• Reduction of Staph Aureus Carriage by Non-Antibiotic NOZIN® Nasal Sanitizer® Antiseptic (NA)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.