Last reviewed · How we verify
Basophil Activation Test
The Basophil Activation Test (BAT) is a flow cytometry-based diagnostic assay that measures basophil degranulation in response to allergen exposure to identify IgE-mediated allergic sensitization.
The Basophil Activation Test (BAT) is a flow cytometry-based diagnostic assay that measures basophil degranulation in response to allergen exposure to identify IgE-mediated allergic sensitization. Used for In vitro diagnosis of IgE-mediated allergic diseases, Assessment of allergic sensitization to specific allergens, Monitoring of allergen immunotherapy response.
At a glance
| Generic name | Basophil Activation Test |
|---|---|
| Sponsor | University Hospital, Rouen |
| Modality | Biologic |
| Therapeutic area | Immunology/Allergy |
| Phase | FDA-approved |
Mechanism of action
BAT detects upregulation of activation markers (CD63, CD203c) on basophil surfaces when patient serum basophils are exposed to specific allergens in vitro. This functional test identifies IgE-mediated allergic responses and can quantify the degree of basophil reactivity, serving as a diagnostic tool for allergy assessment and potentially for monitoring immunotherapy response.
Approved indications
- In vitro diagnosis of IgE-mediated allergic diseases
- Assessment of allergic sensitization to specific allergens
- Monitoring of allergen immunotherapy response
Common side effects
Key clinical trials
- The Basophil Activation Test as a Diagnostic Tool in Pediatric Food Allergy (NA)
- Inhibition of Anaphylaxis by Ibrutinib (PHASE2)
- Impacts of Nitrogen Deposition in the Natural Environment on Pollen Allergy in Belgium (NA)
- Repertoire and Properties of Anti-drug Antibodies Involved in Immediate Hypersensitivity in the Operating Room (NA)
- The Basophil Activation Test For Egg Allergy
- Norwegian Birch Rust Allergy Study
- The Clinical Impact of the Basophil Activation Test to Diagnose Food Allergy (NA)
- Monitoring Allergen Immunotherapy in Allergic Rhinitis
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Basophil Activation Test CI brief — competitive landscape report
- Basophil Activation Test updates RSS · CI watch RSS
- University Hospital, Rouen portfolio CI