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Balanced general anesthesia without morphine
A balanced anesthesia regimen that combines multiple anesthetic agents (typically intravenous hypnotics, volatile anesthetics, and analgesics excluding morphine) to maintain unconsciousness and analgesia during surgery.
A balanced anesthesia regimen that combines multiple anesthetic agents (typically intravenous hypnotics, volatile anesthetics, and analgesics excluding morphine) to maintain unconsciousness and analgesia during surgery. Used for General anesthesia for surgical procedures without morphine-based analgesia.
At a glance
| Generic name | Balanced general anesthesia without morphine |
|---|---|
| Sponsor | Centre Hospitalier Universitaire Dijon |
| Drug class | General anesthetic combination regimen |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Balanced general anesthesia uses a combination of drugs targeting different components of anesthesia—hypnosis, analgesia, and muscle relaxation—without relying on opioids like morphine. This approach typically employs propofol or thiopental for induction, volatile anesthetics (sevoflurane, isoflurane) for maintenance, and non-opioid analgesics (nitrous oxide, regional techniques, or non-morphine analgesics) to achieve surgical anesthesia while potentially reducing opioid-related adverse effects.
Approved indications
- General anesthesia for surgical procedures without morphine-based analgesia
Common side effects
- Postoperative nausea and vomiting
- Hypotension
- Respiratory depression
- Emergence delirium
Key clinical trials
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |