Last reviewed 2026-04-22 · How we verify

Balanced gelatine solution

Balanced gelatine solution provides fluid resuscitation and volume expansion by delivering a colloid suspension that maintains oncotic pressure and restores intravascular volume.

Balanced gelatine solution provides fluid resuscitation and volume expansion by delivering a colloid suspension that maintains oncotic pressure and restores intravascular volume. Used for Hypovolemia and volume replacement during surgery and critical illness, Perioperative fluid resuscitation.

At a glance

Mechanism of action

Balanced gelatine solution is a plasma substitute composed of gelatine (a colloid derived from animal collagen) suspended in a balanced electrolyte solution. It expands intravascular volume and maintains oncotic pressure to counteract hypovolemia and maintain tissue perfusion. The balanced electrolyte composition helps maintain normal electrolyte concentrations during fluid resuscitation.

Approved indications

• Hypovolemia and volume replacement during surgery and critical illness
• Perioperative fluid resuscitation

Common side effects

• Allergic reactions
• Hyperchloremic acidosis
• Coagulopathy
• Acute kidney injury

Key clinical trials

• Gelaspan vs Crystalloid Therapy in Sepsis (PHASE4)
• Gelatin in ICU and Sepsis (PHASE4)
• Biomarker-guided Intervention to Prevent Acute Kidney Injury (NA)
• Impact of Balanced Crystalloid and Colloid Infusion on Haemostasis in Healthy Male Volunteers (NA)
• Biomarker-guided Implementation of the AKI Bundle (NA)
• Study on the Efficacy and Safety of Gelaspan (PHASE3)
• Radiolabel Study In Healthy Volunteers For Insomnia-Targeting Drug (PHASE1)
• A Comparison of Crystalloid Alone Versus Crystalloid Plus Colloid in Shock Resuscitation (NA)

Primary sources

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