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Balanced crystalloid
Balanced crystalloid is an intravenous fluid solution that restores and maintains electrolyte and fluid balance in the body.
Balanced crystalloid is an intravenous fluid solution that restores and maintains electrolyte and fluid balance in the body. Used for Fluid resuscitation and maintenance in perioperative settings, Treatment of hypovolemia and dehydration in critically ill patients, Intraoperative fluid management during surgery.
At a glance
| Generic name | Balanced crystalloid |
|---|---|
| Also known as | Lactated Ringer's solution, Plasma solution, Plasma-Lyte A 148, Multiple electrolyte solution, Plasmalyte; balanced crystalloids |
| Sponsor | National Taiwan University Hospital |
| Drug class | Intravenous fluid / Crystalloid solution |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Anesthesia / Emergency Medicine |
| Phase | FDA-approved |
Mechanism of action
Balanced crystalloid solutions contain water and electrolytes (sodium, potassium, chloride, calcium, magnesium, lactate) in physiologically appropriate concentrations that closely mimic plasma composition. These solutions are administered intravenously to treat dehydration, maintain hemodynamic stability during surgery, and restore intravascular volume in critically ill patients. The balanced electrolyte composition helps prevent hyperchloremic acidosis and other electrolyte disturbances associated with normal saline.
Approved indications
- Fluid resuscitation and maintenance in perioperative settings
- Treatment of hypovolemia and dehydration in critically ill patients
- Intraoperative fluid management during surgery
Common side effects
- Hyperkalemia
- Fluid overload / pulmonary edema
- Hyponatremia
- Phlebitis at infusion site
Key clinical trials
- Gelaspan vs Crystalloid Therapy in Sepsis (PHASE4)
- Precision Resuscitation With Crystalloids in Sepsis (NA)
- Effect of Two Different Fluid Treatment Regimens on Ultrasonographic Upper Airway Measurements (NA)
- Initial Resuscitation for Acute Kidney Injury in Cirrhosis (NA)
- Hydroxyethyl Starch Versus Crystalloid and Postoperative Major Adverse Kidney Complications (PHASE4)
- Evaluating the Clinical Effectiveness of Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury (PHASE4)
- Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PHASE3)
- The AminoECMO Pilot Trial (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Balanced crystalloid CI brief — competitive landscape report
- Balanced crystalloid updates RSS · CI watch RSS
- National Taiwan University Hospital portfolio CI