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Plegisol In Plastic Container (Sodium Chloride)

Baxter · FDA-approved approved Small molecule Quality 44/100

Provides isotonic saline irrigation with mechanical cleansing action for sterile irrigation of body cavities, tissues, wounds, and surgical equipment.

Sodium Chloride Irrigation, USP is a sterile, nonpyrogenic isotonic saline solution indicated for general irrigation, washing, rinsing, and dilution purposes including blood cell washing. The solution provides sodium and chloride ions essential for maintaining fluid and electrolyte balance and is considered compatible with living tissues and organs. Primary contraindications include prohibition from injection by usual parenteral routes and avoidance during electrosurgical procedures. The product serves as a mechanical cleansing agent and vehicle for pharmaceutical preparations in surgical and clinical settings.

At a glance

Generic nameSodium Chloride
SponsorBaxter
Drug classElectrolyte solution
TargetNot specified
ModalitySmall molecule
PhaseFDA-approved
First approval1965

Mechanism of action

Sodium Chloride Irrigation, USP is an isotonic saline solution identical in composition to 0.9% Sodium Chloride Injection, USP (normal saline). The solution dissociates to provide sodium (Na+) and chloride (Cl−) ions. Sodium is the principal cation of extracellular fluid and plays a large role in therapy of fluid and electrolyte disturbances, while chloride has an integral role in buffering action during oxygen and carbon dioxide exchange in red blood cells. The solution is considered generally compatible with living tissues and organs. Distribution and excretion of sodium and chloride are largely controlled by the kidney, which maintains balance between intake and output. Water, an essential constituent of all body tissues accounting for approximately 70% of total body weight, is maintained through various regulatory mechanisms, with sodium playing a major role in maintaining physiologic equilibrium.

Approved indications

No approved indications tracked.

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
FDA labelMechanism, indications, dosing, boxed warnings, drug interactions
ClinicalTrials.govTrial enrolment, design, endpoints, results

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