Last reviewed 2026-04-22 · How we verify

Bacillus Licheniformis

Bacillus licheniformis is a probiotic bacterium that modulates the gut microbiome and immune system to promote health and treat disease.

Bacillus licheniformis is a probiotic bacterium that modulates the gut microbiome and immune system to promote health and treat disease. Used for Clostridium difficile infection (CDI) or recurrent CDI, Inflammatory bowel disease or microbiota dysbiosis-related conditions.

At a glance

Mechanism of action

Bacillus licheniformis is a spore-forming bacterium used as a live biotherapeutic agent that colonizes the gastrointestinal tract and produces metabolites that support beneficial microbiota composition and intestinal barrier function. It may enhance immune tolerance and reduce pathogenic bacterial overgrowth through competitive exclusion and production of antimicrobial compounds. The mechanism leverages the microbiota-immune axis to restore dysbiosis-associated conditions.

Approved indications

• Clostridium difficile infection (CDI) or recurrent CDI
• Inflammatory bowel disease or microbiota dysbiosis-related conditions

Common side effects

• Gastrointestinal symptoms (abdominal discomfort, diarrhea, nausea)
• Fever or systemic inflammatory response

Key clinical trials

• Multimodal Image Technologies Investigate the Role and Mechanism of Probiotics in Improving RBD with Parkinson's Disease (PHASE4)
• Prevention of Radiotherapy Induced Enteropathy by Probiotics (PREP) (PHASE3)
• A New System for GERD Diagnosis and Treatment
• Bacillus Particles Prevent Children Antibiotics Associated Diarrhea (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.