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B Vitamins
B vitamins serve as essential coenzymes in cellular energy metabolism, DNA synthesis, and nervous system function.
B vitamins serve as essential coenzymes in cellular energy metabolism, DNA synthesis, and nervous system function. Used for B vitamin deficiency prevention and treatment, Nutritional supplementation for energy metabolism support.
At a glance
| Generic name | B Vitamins |
|---|---|
| Also known as | Group B |
| Sponsor | Fundação Educacional Serra dos Órgãos |
| Drug class | Vitamin supplement |
| Modality | Small molecule |
| Therapeutic area | Nutritional supplementation / General wellness |
| Phase | FDA-approved |
Mechanism of action
B vitamins (including thiamine, riboflavin, niacin, pantothenic acid, pyridoxine, biotin, folate, and cobalamin) function as cofactors in numerous enzymatic reactions critical for carbohydrate, lipid, and amino acid metabolism. They support mitochondrial ATP production, myelin formation, and homocysteine metabolism. Deficiencies in B vitamins lead to impaired energy production and neurological dysfunction, which supplementation corrects.
Approved indications
- B vitamin deficiency prevention and treatment
- Nutritional supplementation for energy metabolism support
Common side effects
- Gastrointestinal upset (nausea, diarrhea)
- Flushing (niacin)
- Peripheral neuropathy (excessive B6)
Key clinical trials
- Pharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants (PHASE2)
- Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma (PHASE3)
- The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists (PHASE1)
- Iron and Immune Response to Vaccine (IRONMUM) (NA)
- An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM (PHASE3)
- A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions (PHASE3)
- Colon-delivered Riboflavin and Gut Microbiota Composition (NA)
- Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |