Last reviewed 2026-04-23 · How we verify

AZD8848

AZD8848 is a small molecule inhibitor of the PI3K delta and PI3K gamma enzymes.

AZD8848 is a small molecule inhibitor of the PI3K delta and PI3K gamma enzymes. Used for Moderate to severe atopic dermatitis.

At a glance

Mechanism of action

By inhibiting these enzymes, AZD8848 is thought to modulate immune cell function and potentially treat various inflammatory and autoimmune diseases. However, the exact mechanism of action may vary depending on the specific indication and disease being targeted.

Approved indications

• Moderate to severe atopic dermatitis

Common side effects

• Upper respiratory tract infection
• Nasopharyngitis
• Headache
• Musculoskeletal pain

Key clinical trials

• AZD8848 Single Ascending Dose Study (PHASE1)
• The Tolerability and Effects of AZD8848 in Allergic Asthma Subjects Challenged With Inhaled Allergen (PHASE2)
• Efficacy Study in Allergic Rhinitis Patients After Intranasal Administration of AZD8848 (PHASE2)
• Tolerability/Safety of Intranasal AZD8848 in Healthy Male Volunteers and Seasonal Allergic Rhinitis Male Patients Out of Season (PHASE1)
• Tolerability/PoP Study in Allergic Rhinitis After Intranasal Administration of AZD8848 (PHASE1)
• A Study to Investigate the Impact of Dose and Dosing Frequency of AZD8848 on the Response on Biomarkers (PHASE1)
• Study to Investigate the Safety and Tolerability of AZD8848 in Butyrylcholinesterase Deficient Subjects (PHASE1)
• To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects (PHASE1)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.