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Azathioprine OR Mesalazine
Azathioprine OR Mesalazine is a Immunosuppressant and anti-inflammatory combination Small molecule drug developed by Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives. It is currently in Phase 3 development for Inflammatory bowel disease (Crohn's disease or ulcerative colitis), Induction and maintenance of remission in IBD.
This is a combination therapy study comparing azathioprine (an immunosuppressant) and mesalazine (an anti-inflammatory) for inflammatory bowel disease.
This is a combination therapy study comparing azathioprine (an immunosuppressant) and mesalazine (an anti-inflammatory) for inflammatory bowel disease. Used for Inflammatory bowel disease (Crohn's disease or ulcerative colitis), Induction and maintenance of remission in IBD.
At a glance
| Generic name | Azathioprine OR Mesalazine |
|---|---|
| Sponsor | Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives |
| Drug class | Immunosuppressant and anti-inflammatory combination |
| Target | Purine metabolism (azathioprine); NF-κB pathway (mesalazine) |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology / Immunology |
| Phase | Phase 3 |
Mechanism of action
Azathioprine is a purine analog that suppresses T-cell mediated immunity by inhibiting DNA synthesis in lymphocytes. Mesalazine (5-aminosalicylic acid) acts locally in the colon to reduce inflammation through inhibition of NF-κB and production of anti-inflammatory mediators. Together they target both immune suppression and local mucosal inflammation in IBD.
Approved indications
- Inflammatory bowel disease (Crohn's disease or ulcerative colitis)
- Induction and maintenance of remission in IBD
Common side effects
- Nausea and gastrointestinal upset
- Bone marrow suppression
- Hepatotoxicity
- Pancreatitis
- Headache
- Rash
Key clinical trials
- Chronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis (NA)
- Maintaining or Stopping Immunosuppressive Therapy in Patients With ANCA Vasculitis and End-stage Renal Disease (PHASE3)
- Combined Immunosuppression for Pediatric Crohn's Disease (PHASE4)
- This Study is a Non-interventional Disease Registry of Adolescent and Adult Patients With Atopic Dermatitis Who Initiate or Switch Any Systemic Treatment
- Activation of Autophagy and Suppression of Apoptosis by Dapagliflozin Attenuates Inflammatory Bowel Disease (PHASE2, PHASE3)
- Effectiveness of Ozanimod in Patients With Steroid-Dependent Ulcerative Colitis
- The Efficacy and Safety of Infliximab Combination With Azathioprine in Crohn's Disease in Children (NA)
- Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Azathioprine OR Mesalazine CI brief — competitive landscape report
- Azathioprine OR Mesalazine updates RSS · CI watch RSS
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives portfolio CI
Frequently asked questions about Azathioprine OR Mesalazine
What is Azathioprine OR Mesalazine?
How does Azathioprine OR Mesalazine work?
What is Azathioprine OR Mesalazine used for?
Who makes Azathioprine OR Mesalazine?
What drug class is Azathioprine OR Mesalazine in?
What development phase is Azathioprine OR Mesalazine in?
What are the side effects of Azathioprine OR Mesalazine?
What does Azathioprine OR Mesalazine target?
Related
- Drug class: All Immunosuppressant and anti-inflammatory combination drugs
- Target: All drugs targeting Purine metabolism (azathioprine); NF-κB pathway (mesalazine)
- Manufacturer: Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives — full pipeline
- Therapeutic area: All drugs in Gastroenterology / Immunology
- Indication: Drugs for Inflammatory bowel disease (Crohn's disease or ulcerative colitis)
- Indication: Drugs for Induction and maintenance of remission in IBD
- Compare: Azathioprine OR Mesalazine vs similar drugs
- Pricing: Azathioprine OR Mesalazine cost, discount & access