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Avibactam sodium/Ceftazidime hydrate (avibactam-sodium-ceftazidime-hydrate)
Avibactam sodium/Ceftazidime hydrate (generic name: avibactam-sodium-ceftazidime-hydrate) is a drug developed by Pfizer Inc.. It is currently in preclinical development.
Avibactam sodium/ceftazidime hydrate (Zavicefta®) is a fixed-dose combination antibiotic developed by Pfizer that pairs a third-generation cephalosporin (ceftazidime) with a novel beta-lactamase inhibitor (avibactam) to combat multidrug-resistant gram-negative bacterial infections. The combination works by protecting ceftazidime from enzymatic degradation by beta-lactamases while simultaneously providing direct bactericidal activity, restoring efficacy against pathogens resistant to cephalosporins alone. Zavicefta is FDA-approved for complicated intra-abdominal infections, complicated urinary tract infections, and hospital-acquired/ventilator-associated bacterial pneumonia, with regulatory approvals across major markets including the EMA. The drug represents a significant advance in treating carbapenem-resistant Enterobacteriaceae (CRE) and Pseudomonas aeruginosa, addressing a critical unmet need in serious gram-negative infections where resistance mechanisms have rendered traditional beta-lactams ineffective. Commercial uptake has been substantial, with peak annual sales exceeding $500 million globally, driven by high-acuity hospital use and the growing prevalence of multidrug-resistant pathogens. Pfizer continues to expand the clinical profile through additional indications and formulation development, including pediatric studies and sepsis-focused trials.
At a glance
| Generic name | avibactam-sodium-ceftazidime-hydrate |
|---|---|
| Sponsor | Pfizer Inc. |
| Phase | preclinical |
Approved indications
Common side effects
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Avibactam sodium/Ceftazidime hydrate CI brief — competitive landscape report
- Avibactam sodium/Ceftazidime hydrate updates RSS · CI watch RSS
- Pfizer Inc. portfolio CI
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Related
- Manufacturer: Pfizer Inc. — full pipeline