Last reviewed · How we verify
Avycaz (AVIBACTAM)
EMBLAVEO is an antibacterial drug.
At a glance
| Generic name | AVIBACTAM |
|---|---|
| Sponsor | Cerexa Inc |
| Drug class | beta Lactamase Inhibitor [EPC] |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
| First approval | 2015 |
Mechanism of action
AVYCAZ is an antibacterial drug see Clinical Pharmacology 12.4 ].
Approved indications
- Bacterial urinary infection
- Infectious disease of abdomen
- Pyelonephritis
Common side effects
- Diarrhea
- Nausea
- Vomiting
- Headache
- Dizziness
- Infusion site phlebitis
- Rash
- Abdominal Pain
- Death
- Increased Mortality
Key clinical trials
- Individualized Precision Therapy With Ceftazidime and Avibactam Guided by PK/PD in Geriatric Populations
- Study of 2 Medicines (Aztreonam and Avibactam) Compared to Best Available Therapy for Serious Gram-negative Infections (PHASE2)
- Real-World Effectiveness of Aztreonam-Avibactam Against MBL-Producing CRE
- A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH) (PHASE2)
- Different Administration Regimens of CAZ-AVI in Combination With ATM for the Treatment of CR-GNB (PHASE4)
- Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex (PHASE2)
- A Study to Evaluate the Efficacy and Safety of Meropenem and Pralurbactam in HABP/VABP (PHASE3)
- Effect of Ceftazidime-Avibactam on Carbapenemase-Producing Klebsiella Pneumoniae
Patents
| Patent | Expiry | Type |
|---|---|---|
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
| FDA Orange Book | Patents + exclusivity |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Avycaz CI brief — competitive landscape report
- Avycaz updates RSS · CI watch RSS
- Cerexa Inc portfolio CI