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Avastin intravitreal injection
Avastin intravitreal injection is a VEGF inhibitor (monoclonal antibody) Small molecule drug developed by Ophthalmological Association Edelweiss. It is currently in Phase 3 development for Diabetic macular edema, Retinal vein occlusion (branch and central), Age-related macular degeneration (wet/neovascular). Also known as: Avastin.
Avastin (bevacizumab) is a monoclonal antibody that blocks vascular endothelial growth factor (VEGF) to inhibit abnormal blood vessel formation in the eye.
Avastin (bevacizumab) is a monoclonal antibody that blocks vascular endothelial growth factor (VEGF) to inhibit abnormal blood vessel formation in the eye. Used for Diabetic macular edema, Retinal vein occlusion (branch and central), Age-related macular degeneration (wet/neovascular).
At a glance
| Generic name | Avastin intravitreal injection |
|---|---|
| Also known as | Avastin |
| Sponsor | Ophthalmological Association Edelweiss |
| Drug class | VEGF inhibitor (monoclonal antibody) |
| Target | VEGF (Vascular Endothelial Growth Factor) |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 3 |
Mechanism of action
When administered as an intravitreal injection, bevacizumab binds to and neutralizes VEGF, a key driver of pathological neovascularization in retinal diseases. By reducing VEGF signaling, the drug suppresses the growth of abnormal blood vessels and reduces vascular permeability, thereby reducing retinal edema and preventing vision loss in conditions characterized by excessive angiogenesis.
Approved indications
- Diabetic macular edema
- Retinal vein occlusion (branch and central)
- Age-related macular degeneration (wet/neovascular)
- Proliferative diabetic retinopathy
Common side effects
- Endophthalmitis
- Retinal detachment
- Cataract progression
- Intraocular pressure elevation
- Floaters/vitreous opacities
Key clinical trials
- Speculum-Free Intravitreal Injection Using Cotton-Tipped Applicator Retraction: A Randomized Trial of Pain, Procedure Time, Patient Satisfaction, and Safety (NA)
- Clinical Study to Evaluate PRO-169 for Diabetic Macular Edema (PHASE3)
- Safety and Immunogenicity of PRO-169 in Patients With Diabetic Macular Edema (PHASE1)
- Bevacizumab Treatment For Type 1 ROP (PHASE2)
- Comparison of Bevacizumab and Aflibercept in Treatment of Diabetic Macular Edema (NA)
- Interest of Intravitreal Injections of Anti-VEGF as Initial and Adjuvant Treatment in Coats Disease (PHASE3)
- The Sahlgrenska Anti-VEGF Study (PHASE2)
- Pharmacogenomics of antiVEGF in Patients With Age-Associated Macular Degeneration (AMD) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Avastin intravitreal injection CI brief — competitive landscape report
- Avastin intravitreal injection updates RSS · CI watch RSS
- Ophthalmological Association Edelweiss portfolio CI
Frequently asked questions about Avastin intravitreal injection
What is Avastin intravitreal injection?
How does Avastin intravitreal injection work?
What is Avastin intravitreal injection used for?
Who makes Avastin intravitreal injection?
Is Avastin intravitreal injection also known as anything else?
What drug class is Avastin intravitreal injection in?
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What does Avastin intravitreal injection target?
Related
- Drug class: All VEGF inhibitor (monoclonal antibody) drugs
- Target: All drugs targeting VEGF (Vascular Endothelial Growth Factor)
- Manufacturer: Ophthalmological Association Edelweiss — full pipeline
- Therapeutic area: All drugs in Ophthalmology
- Indication: Drugs for Diabetic macular edema
- Indication: Drugs for Retinal vein occlusion (branch and central)
- Indication: Drugs for Age-related macular degeneration (wet/neovascular)
- Also known as: Avastin
- Compare: Avastin intravitreal injection vs similar drugs
- Pricing: Avastin intravitreal injection cost, discount & access