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Avastin in combination with Roferon-A
Avastin in combination with Roferon-A is a Antiangiogenic agent and Immunomodulator Small molecule drug developed by Central European Society for Anticancer Drug Research. It is currently in Phase 2 development for Metastatic colorectal cancer, Non-small cell lung cancer. Also known as: Bevacizumab in combination with Interfereon-alfa.
Avastin (bevacizumab) inhibits angiogenesis by binding to vascular endothelial growth factor (VEGF), while Roferon-A (interferon alfa-2a) modulates the immune response and has antiproliferative effects.
Avastin (bevacizumab) inhibits angiogenesis by binding to vascular endothelial growth factor (VEGF), while Roferon-A (interferon alfa-2a) modulates the immune response and has antiproliferative effects. Used for Metastatic colorectal cancer, Non-small cell lung cancer.
At a glance
| Generic name | Avastin in combination with Roferon-A |
|---|---|
| Also known as | Bevacizumab in combination with Interfereon-alfa |
| Sponsor | Central European Society for Anticancer Drug Research |
| Drug class | Antiangiogenic agent and Immunomodulator |
| Target | VEGF |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
Avastin works by binding to VEGF, preventing its interaction with its receptor and thus inhibiting the formation of new blood vessels that tumors need to grow. Roferon-A, on the other hand, stimulates the immune system to recognize and attack cancer cells, and also has direct antiproliferative effects on tumor cells.
Approved indications
- Metastatic colorectal cancer
- Non-small cell lung cancer
Common side effects
- Hypertension
- Fatigue
- Headache
Key clinical trials
- A Study to Assess the Safety and Tolerability of Atezolizumab in Combination With Other Immune-Modulating Therapies in Participants With Locally Advanced or Metastatic Solid Tumors (PHASE1)
- Sequential Therapy in Metastatic Renal Cell Carinoma (PHASE2)
- Bevacizumab in Metastatic Renal Cancer
- A Study of Avastin (Bevacizumab) in Combination With Low-Dose-Interferon in Patients With Metastatic Clear Cell Renal Cell Carcinoma (RCC). (PHASE2)
- A Study of Avastin (Bevacizumab) in Combination With Standard Therapy in Patients With Metastatic Renal Cell Cancer. (PHASE2)
- Combination of Temsirolimus and Bevacizumab in Patient With Metastatic Renal Cell Carcinoma (PHASE2)
- Bevacizumab, Dacarbazine and Interferon-Alfa to Treat Metastatic Melanoma (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Avastin in combination with Roferon-A CI brief — competitive landscape report
- Avastin in combination with Roferon-A updates RSS · CI watch RSS
- Central European Society for Anticancer Drug Research portfolio CI
Frequently asked questions about Avastin in combination with Roferon-A
What is Avastin in combination with Roferon-A?
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Is Avastin in combination with Roferon-A also known as anything else?
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Related
- Drug class: All Antiangiogenic agent and Immunomodulator drugs
- Target: All drugs targeting VEGF
- Manufacturer: Central European Society for Anticancer Drug Research — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Metastatic colorectal cancer
- Indication: Drugs for Non-small cell lung cancer
- Also known as: Bevacizumab in combination with Interfereon-alfa
- Compare: Avastin in combination with Roferon-A vs similar drugs
- Pricing: Avastin in combination with Roferon-A cost, discount & access