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Autologous bone marrow stem cell
Autologous bone marrow stem cell therapy involves using a patient's own stem cells to stimulate the growth of new bone tissue.
Autologous bone marrow stem cell therapy involves using a patient's own stem cells to stimulate the growth of new bone tissue. Used for Treatment of multiple myeloma and other hematologic malignancies.
At a glance
| Generic name | Autologous bone marrow stem cell |
|---|---|
| Sponsor | Manipal Acunova Ltd. |
| Drug class | Stem cell therapy |
| Modality | Biologic |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
This process typically involves collecting the patient's bone marrow stem cells, processing them to remove any diseased cells, and then reinfusing them into the patient's body. The goal is to stimulate the growth of new bone tissue, which can help to repair damaged or diseased bone.
Approved indications
- Treatment of multiple myeloma and other hematologic malignancies
Common side effects
- Bone marrow suppression
- Infection
- Nausea and vomiting
Key clinical trials
- Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (PHASE3)
- HIV Antigen-specific T-cells Targeting Conserved Epitopes (HST-NEETs) BMTCTN1903 (PHASE2)
- A Study of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly-Diagnosed Multiple Myeloma (PHASE2)
- Implantation of Engineered Cartilage Grafts for Treatment of Patellofemoral Osteoarthritis Versus Surgical Comparators. (PHASE2)
- Rituximab With or Without Stem Cell Transplant in Treating Patients With Minimal Residual Disease-Negative Mantle Cell Lymphoma in First Complete Remission (PHASE3)
- Study of Mesenchymal Autologous Stem Cells as Regenerative Treatment for Multiple Sclerosis (PHASE1, PHASE2)
- Exercise in Patients Undergoing Autologous Stem Cell Transplantation: A Randomized Controlled Trial (NA)
- A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |