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Tracrium Preservative Free (ATRACURIUM)
Tracrium Preservative Free (Atracurium) is a nondepolarizing neuromuscular blocker, a small molecule drug class, that targets the neuronal acetylcholine receptor subunit alpha-3. It is used for general anesthesia, muscle relaxation, and endotracheal intubation. Originally developed, it is now owned by Hospira and has been FDA approved since 1983. Tracrium Preservative Free is available as a generic medication with 11 manufacturers and is off-patent. Key safety considerations include its short half-life of 0.31 hours.
At a glance
| Generic name | ATRACURIUM |
|---|---|
| Sponsor | Hospira |
| Drug class | Nondepolarizing Neuromuscular Blocker |
| Target | Neuronal acetylcholine receptor subunit alpha-3 |
| Modality | Small molecule |
| Therapeutic area | Neuroscience |
| Phase | FDA-approved |
| First approval | 1983 |
Approved indications
- General anesthesia
- Muscle relaxation, function
- Skeletal Muscle Relaxation for Endotracheal Intubation
Common side effects
- Skin Flush
- Erythema
- Itching
- Wheezing/Bronchial Secretions
- Hives
- Mean Arterial Pressure Increase
- Mean Arterial Pressure Decrease
- Heart Rate Increase
- Heart Rate Decrease
Drug interactions
- enflurane
- isoflurane
- halothane
- aminoglycosides
- polymyxins
- lithium
- magnesium salts
- procainamide
- quinidine
- other muscle relaxants
- succinylcholine
Key clinical trials
- Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy (PHASE4)
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- A Comparative Study Between Combination of Propofol and Dexmedetomidine Versus Propofol Alone in Anesthesia for Rigid Bronchoscopy by Using the Patient State Index Monitor (PHASE4)
- Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery (PHASE4)
- Effect of Nalbuphine on Hemodynamic Response During Laryngoscopy and Intubation (NA)
- Effect of Total Intravenous Anesthesia vs Inhalational Anesthesia on the Level of Inflammatory Markers (NA)
- Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy. (NA)
- Continuous Spinal Anesthesia in Renal Transplantation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tracrium Preservative Free CI brief — competitive landscape report
- Tracrium Preservative Free updates RSS · CI watch RSS