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atorvastatin, aspirin, losartan, amlodipine

Russian Cardiology Research and Production Center · FDA-approved active Small molecule

atorvastatin, aspirin, losartan, amlodipine is a Fixed-dose combination: HMG-CoA reductase inhibitor, antiplatelet agent, angiotensin II receptor antagonist, and calcium channel blocker Small molecule drug developed by Russian Cardiology Research and Production Center. It is currently FDA-approved for Secondary prevention of cardiovascular events in patients with coronary artery disease or high cardiovascular risk, Hypertension management in patients requiring lipid-lowering and antiplatelet therapy.

This is a fixed-dose combination of four cardiovascular agents that work synergistically to reduce cholesterol, prevent thrombosis, lower blood pressure, and improve coronary blood flow.

This is a fixed-dose combination of four cardiovascular agents that work synergistically to reduce cholesterol, prevent thrombosis, lower blood pressure, and improve coronary blood flow. Used for Secondary prevention of cardiovascular events in patients with coronary artery disease or high cardiovascular risk, Hypertension management in patients requiring lipid-lowering and antiplatelet therapy.

At a glance

Generic nameatorvastatin, aspirin, losartan, amlodipine
SponsorRussian Cardiology Research and Production Center
Drug classFixed-dose combination: HMG-CoA reductase inhibitor, antiplatelet agent, angiotensin II receptor antagonist, and calcium channel blocker
TargetMultiple: HMG-CoA reductase, cyclooxygenase, AT1 receptor, L-type calcium channel
ModalitySmall molecule
Therapeutic areaCardiovascular
PhaseFDA-approved

Mechanism of action

Atorvastatin inhibits HMG-CoA reductase to lower LDL cholesterol and reduce atherosclerotic plaque formation. Aspirin irreversibly inhibits cyclooxygenase to prevent platelet aggregation and thrombotic events. Losartan blocks angiotensin II type 1 receptors to reduce vasoconstriction and lower blood pressure. Amlodipine blocks L-type calcium channels in vascular smooth muscle to cause vasodilation and further reduce blood pressure and improve myocardial oxygen supply.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about atorvastatin, aspirin, losartan, amlodipine

What is atorvastatin, aspirin, losartan, amlodipine?

atorvastatin, aspirin, losartan, amlodipine is a Fixed-dose combination: HMG-CoA reductase inhibitor, antiplatelet agent, angiotensin II receptor antagonist, and calcium channel blocker drug developed by Russian Cardiology Research and Production Center, indicated for Secondary prevention of cardiovascular events in patients with coronary artery disease or high cardiovascular risk, Hypertension management in patients requiring lipid-lowering and antiplatelet therapy.

How does atorvastatin, aspirin, losartan, amlodipine work?

This is a fixed-dose combination of four cardiovascular agents that work synergistically to reduce cholesterol, prevent thrombosis, lower blood pressure, and improve coronary blood flow.

What is atorvastatin, aspirin, losartan, amlodipine used for?

atorvastatin, aspirin, losartan, amlodipine is indicated for Secondary prevention of cardiovascular events in patients with coronary artery disease or high cardiovascular risk, Hypertension management in patients requiring lipid-lowering and antiplatelet therapy.

Who makes atorvastatin, aspirin, losartan, amlodipine?

atorvastatin, aspirin, losartan, amlodipine is developed and marketed by Russian Cardiology Research and Production Center (see full Russian Cardiology Research and Production Center pipeline at /company/russian-cardiology-research-and-production-center).

What drug class is atorvastatin, aspirin, losartan, amlodipine in?

atorvastatin, aspirin, losartan, amlodipine belongs to the Fixed-dose combination: HMG-CoA reductase inhibitor, antiplatelet agent, angiotensin II receptor antagonist, and calcium channel blocker class. See all Fixed-dose combination: HMG-CoA reductase inhibitor, antiplatelet agent, angiotensin II receptor antagonist, and calcium channel blocker drugs at /class/fixed-dose-combination-hmg-coa-reductase-inhibitor-antiplatelet-agent-angiotensin-ii-receptor-antagonist-and-calcium-channel-blocker.

What development phase is atorvastatin, aspirin, losartan, amlodipine in?

atorvastatin, aspirin, losartan, amlodipine is FDA-approved (marketed).

What are the side effects of atorvastatin, aspirin, losartan, amlodipine?

Common side effects of atorvastatin, aspirin, losartan, amlodipine include Muscle pain or myalgia, Headache, Dizziness, Gastrointestinal upset, Peripheral edema, Bleeding or bruising.

What does atorvastatin, aspirin, losartan, amlodipine target?

atorvastatin, aspirin, losartan, amlodipine targets Multiple: HMG-CoA reductase, cyclooxygenase, AT1 receptor, L-type calcium channel and is a Fixed-dose combination: HMG-CoA reductase inhibitor, antiplatelet agent, angiotensin II receptor antagonist, and calcium channel blocker.

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