Last reviewed 2026-04-22 · How we verify

Atenolol Thiazide

Atenolol Thiazide is a combination drug that reduces blood pressure by blocking beta-adrenergic receptors (atenolol) and promoting sodium and water excretion through the kidneys (thiazide diuretic).

Atenolol Thiazide is a combination drug that reduces blood pressure by blocking beta-adrenergic receptors (atenolol) and promoting sodium and water excretion through the kidneys (thiazide diuretic). Used for Hypertension, Angina pectoris.

At a glance

Mechanism of action

Atenolol, a selective beta-1 blocker, decreases heart rate and cardiac contractility, reducing blood pressure and myocardial oxygen demand. The thiazide component inhibits sodium reabsorption in the distal convoluted tubule, promoting diuresis and reducing blood volume. Together, these complementary mechanisms provide additive antihypertensive effects.

Approved indications

• Hypertension
• Angina pectoris

Common side effects

• Fatigue
• Dizziness
• Hypokalemia
• Hyperglycemia
• Sexual dysfunction
• Bradycardia

Key clinical trials

• Losartan and HCTZ and Amlodipine vs Atenolol and Amlodipine (0954A-309)(COMPLETED) (PHASE4)
• The International Polycap Study 3 (TIPS-3) (PHASE3)
• ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
• Nephropathy In Type 2 Diabetes and Cardio-renal Events (PHASE4)
• Rural Andhra Pradesh Cardiovascular Prevention Study (RAPCAPS) (PHASE4)
• Pharmacogenomic Evaluation of Antihypertensive Responses (PHASE4)
• Matão Controlling Hypertension (MatCH Study): Rationale and Design (EARLY_PHASE1)
• EBMtrialcentral- Comparing Initial Diuretic Therapies Using a Collaborative Network (PHASE4)

Primary sources

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