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Atazanavir-Ritonavir/ Stavidine / Lamivudine
Atazanavir-Ritonavir/ Stavidine / Lamivudine is a Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors) Small molecule drug developed by Bristol-Myers Squibb. It is currently FDA-approved for HIV-1 infection in treatment-naïve and treatment-experienced patients. Also known as: Reyataz.
This combination inhibits HIV protease and reverse transcriptase to block viral replication at multiple steps in the HIV life cycle.
This combination inhibits HIV protease and reverse transcriptase to block viral replication at multiple steps in the HIV life cycle. Used for HIV-1 infection in treatment-naïve and treatment-experienced patients.
At a glance
| Generic name | Atazanavir-Ritonavir/ Stavidine / Lamivudine |
|---|---|
| Also known as | Reyataz |
| Sponsor | Bristol-Myers Squibb |
| Drug class | Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors) |
| Target | HIV protease, HIV reverse transcriptase |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Virology |
| Phase | FDA-approved |
Mechanism of action
Atazanavir is a protease inhibitor that prevents HIV protease from cleaving viral polyproteins, while ritonavir boosts atazanavir levels by inhibiting its metabolism. Stavudine and lamivudine are nucleoside reverse transcriptase inhibitors that block the enzyme responsible for converting HIV RNA into DNA, preventing viral integration into host cells.
Approved indications
- HIV-1 infection in treatment-naïve and treatment-experienced patients
Common side effects
- Hyperbilirubinemia (unconjugated)
- Nausea
- Diarrhea
- Headache
- Peripheral neuropathy (stavudine-related)
- Lipodystrophy (stavudine-related)
- Pancreatitis
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Atazanavir-Ritonavir/ Stavidine / Lamivudine CI brief — competitive landscape report
- Atazanavir-Ritonavir/ Stavidine / Lamivudine updates RSS · CI watch RSS
- Bristol-Myers Squibb portfolio CI
Frequently asked questions about Atazanavir-Ritonavir/ Stavidine / Lamivudine
What is Atazanavir-Ritonavir/ Stavidine / Lamivudine?
How does Atazanavir-Ritonavir/ Stavidine / Lamivudine work?
What is Atazanavir-Ritonavir/ Stavidine / Lamivudine used for?
Who makes Atazanavir-Ritonavir/ Stavidine / Lamivudine?
Is Atazanavir-Ritonavir/ Stavidine / Lamivudine also known as anything else?
What drug class is Atazanavir-Ritonavir/ Stavidine / Lamivudine in?
What development phase is Atazanavir-Ritonavir/ Stavidine / Lamivudine in?
What are the side effects of Atazanavir-Ritonavir/ Stavidine / Lamivudine?
What does Atazanavir-Ritonavir/ Stavidine / Lamivudine target?
Related
- Drug class: All Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors) drugs
- Target: All drugs targeting HIV protease, HIV reverse transcriptase
- Manufacturer: Bristol-Myers Squibb — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Virology
- Indication: Drugs for HIV-1 infection in treatment-naïve and treatment-experienced patients
- Also known as: Reyataz
- Compare: Atazanavir-Ritonavir/ Stavidine / Lamivudine vs similar drugs
- Pricing: Atazanavir-Ritonavir/ Stavidine / Lamivudine cost, discount & access