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Aromatase Inhibitor and Growth Hormone
Aromatase Inhibitor and Growth Hormone is a Aromatase inhibitor + Growth hormone combination Small molecule drug developed by Nemours Children's Clinic. It is currently in Phase 3 development for Growth hormone deficiency in children, Short stature in pediatric patients. Also known as: Arimidex (Anastrozole), Femara (Letrozole), Nutropin (Somatropin), Genotropin (Somatropin).
This combination therapy inhibits aromatase to reduce estrogen production while supplementing growth hormone to promote linear growth in pediatric patients.
This combination therapy inhibits aromatase to reduce estrogen production while supplementing growth hormone to promote linear growth in pediatric patients. Used for Growth hormone deficiency in children, Short stature in pediatric patients.
At a glance
| Generic name | Aromatase Inhibitor and Growth Hormone |
|---|---|
| Also known as | Arimidex (Anastrozole), Femara (Letrozole), Nutropin (Somatropin), Genotropin (Somatropin) |
| Sponsor | Nemours Children's Clinic |
| Drug class | Aromatase inhibitor + Growth hormone combination |
| Target | Aromatase (CYP19A1) and growth hormone receptor (GHR) |
| Modality | Small molecule |
| Therapeutic area | Pediatric Endocrinology |
| Phase | Phase 3 |
Mechanism of action
Aromatase inhibitors block the conversion of androgens to estrogen, which can help delay epiphyseal closure and extend the growth window in children with growth disorders. Concurrent growth hormone supplementation directly stimulates linear growth through IGF-1 signaling and anabolic effects on bone and muscle tissue. Together, these agents aim to maximize final adult height in growth-hormone-deficient or growth-restricted pediatric populations.
Approved indications
- Growth hormone deficiency in children
- Short stature in pediatric patients
Common side effects
- Gynecomastia (reduced by aromatase inhibition)
- Injection site reactions (growth hormone)
- Headache
- Arthralgia
- Fluid retention
Key clinical trials
- A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma (PHASE1, PHASE2)
- TREATMENT AND MONITORING PATTERNS AND CLINICAL OUTCOMES IN PATIENTS RECEIVING PALBOCICLIB COMBINATION TREATMENT (WITH AI OR FULVESTRANT) FOR HR+/HER2- A/MBC IN A COMMUNITY ONCOLOGY SETTING.
- Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer (PHASE3)
- A Study of Single Dose of BL0175 in Postmenopausal Women (PHASE1)
- Study to Compare Overall Survival in Medicare Patients With Metastatic Breast Cancer Treated With a Medicine Called Palbociclib in Combination With Aromatase Inhibitor and Aromatase Inhibitor by Itself.
- RADIANT: Pre-op Radiation With Abemaciclib and Letrozole (PHASE1)
- Study of 2 Ribociclib Doses in Combination With Aromatase Inhibitors in Women With HR+, HER2- Advanced Breast Cancer (PHASE2)
- AKT Inhibitor, Ipatasertib, With Endocrine and CDK 4/6 Inhibitor for Patients With Metastatic Breast Cancer (TAKTIC) (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Aromatase Inhibitor and Growth Hormone CI brief — competitive landscape report
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- Nemours Children's Clinic portfolio CI
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Related
- Drug class: All Aromatase inhibitor + Growth hormone combination drugs
- Target: All drugs targeting Aromatase (CYP19A1) and growth hormone receptor (GHR)
- Manufacturer: Nemours Children's Clinic — full pipeline
- Therapeutic area: All drugs in Pediatric Endocrinology
- Indication: Drugs for Growth hormone deficiency in children
- Indication: Drugs for Short stature in pediatric patients
- Also known as: Arimidex (Anastrozole), Femara (Letrozole), Nutropin (Somatropin), Genotropin (Somatropin)
- Compare: Aromatase Inhibitor and Growth Hormone vs similar drugs
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