Last reviewed 2026-04-23 · How we verify

Any oral opioid

Activates opioid receptors in the brain to produce analgesia.

Activates opioid receptors in the brain to produce analgesia. Used for Chronic pain, Acute pain.

At a glance

Mechanism of action

Opioid receptors are G protein-coupled receptors that, when activated, can lead to a variety of downstream effects including analgesia, euphoria, and respiratory depression. Activation of these receptors can also lead to physical dependence and addiction.

Approved indications

• Chronic pain
• Acute pain

Common side effects

• Nausea
• Vomiting
• Constipation
• Dizziness
• Headache

Key clinical trials

• Virtual Reality for Postoperative Recovery After Major Abdominal Surgery (NA)
• Effect of Academic Detailing on Opioid Prescribing by Dentists to Adolescents and Young Adults (NA)
• Erector Spinae Plane Block for Pain Control After Open Abdominal Surgery (NA)
• Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
• The Ultrasound Guided Pericapsular Nerve Group and Anterior Quadratus Lumborum Blocks in Hip Replacement Surgeries (PHASE4)
• Comparing Thoracolumbar Interfascial and Quadro Iliac Plane Blocks on Postoperative Opioid Use Following Lumbar Microsurgery (NA)
• Analgesic Techniques for Rib Fractures (PHASE4)
• A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis (PHASE3)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Any oral opioid CI brief — competitive landscape report
• Any oral opioid updates RSS · CI watch RSS
• Montefiore Medical Center portfolio CI