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Antiretroviral medications
Antiretroviral medications is a Antiretroviral agents (multiple classes: NRTIs, NNRTIs, PIs, INSTIs, entry inhibitors) Small molecule drug developed by French National Agency for Research on AIDS and Viral Hepatitis. It is currently in Phase 3 development for HIV-1 infection, HIV-2 infection.
Antiretroviral medications inhibit HIV replication by targeting viral enzymes or blocking viral entry into CD4+ T cells.
Antiretroviral medications inhibit HIV replication by targeting viral enzymes or blocking viral entry into CD4+ T cells. Used for HIV-1 infection, HIV-2 infection.
At a glance
| Generic name | Antiretroviral medications |
|---|---|
| Sponsor | French National Agency for Research on AIDS and Viral Hepatitis |
| Drug class | Antiretroviral agents (multiple classes: NRTIs, NNRTIs, PIs, INSTIs, entry inhibitors) |
| Target | HIV reverse transcriptase, HIV protease, HIV integrase, CCR5, CXCR4, gp120/gp41 |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Virology |
| Phase | Phase 3 |
Mechanism of action
Antiretrovirals work through multiple mechanisms depending on drug class: reverse transcriptase inhibitors block viral RNA-to-DNA conversion, protease inhibitors prevent viral protein maturation, integrase inhibitors block viral DNA integration into the host genome, and entry inhibitors prevent viral attachment or fusion with CD4+ cells. These drugs are typically used in combination (highly active antiretroviral therapy, HAART) to suppress viral load and restore immune function.
Approved indications
- HIV-1 infection
- HIV-2 infection
Common side effects
- Nausea
- Diarrhea
- Headache
- Lipodystrophy
- Hepatotoxicity
- Peripheral neuropathy
- Rash
Key clinical trials
- Lenacapavir Intensification to Disrupt HIV Reservoirs in Virologically Suppressed People With HIV Receiving Antiretroviral Therapy (PHASE1)
- Liver Fibrosis in HIV-Infected Patients With Elevated Liver Enzymes on Antiretroviral Therapy
- A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062) (PHASE2, PHASE3)
- Imaging and Biopsy of People With HIV-1 Undergoing Analytic Treatment Interruption (PHASE2)
- Evaluation of Multiple Interventions to Improve HIV Treatment Outcomes Among People Who Inject Drugs in India (NA)
- A Trial of 2 Options for Second Line Combination Antiretroviral Therapy Following Virological Failure of a Standard Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)+2N(t)RTI First Line Regimen (PHASE4)
- Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV (PHASE2, PHASE3)
- An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Antiretroviral medications CI brief — competitive landscape report
- Antiretroviral medications updates RSS · CI watch RSS
- French National Agency for Research on AIDS and Viral Hepatitis portfolio CI
Frequently asked questions about Antiretroviral medications
What is Antiretroviral medications?
How does Antiretroviral medications work?
What is Antiretroviral medications used for?
Who makes Antiretroviral medications?
What drug class is Antiretroviral medications in?
What development phase is Antiretroviral medications in?
What are the side effects of Antiretroviral medications?
What does Antiretroviral medications target?
Related
- Drug class: All Antiretroviral agents (multiple classes: NRTIs, NNRTIs, PIs, INSTIs, entry inhibitors) drugs
- Target: All drugs targeting HIV reverse transcriptase, HIV protease, HIV integrase, CCR5, CXCR4, gp120/gp41
- Manufacturer: French National Agency for Research on AIDS and Viral Hepatitis — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Virology
- Indication: Drugs for HIV-1 infection
- Indication: Drugs for HIV-2 infection
- Compare: Antiretroviral medications vs similar drugs
- Pricing: Antiretroviral medications cost, discount & access