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Antihistamine Cetirizine Hydrochloride
Antihistamine Cetirizine Hydrochloride is a H1-receptor antagonist (second-generation antihistamine) Small molecule drug developed by Goldman, Butterwick, Fitzpatrick and Groff. It is currently FDA-approved for Allergic rhinitis (seasonal and perennial), Chronic urticaria, Allergic conjunctivitis.
Cetirizine hydrochloride blocks histamine H1 receptors on cells, preventing histamine-mediated allergic responses.
Cetirizine hydrochloride blocks histamine H1 receptors on cells, preventing histamine-mediated allergic responses. Used for Allergic rhinitis (seasonal and perennial), Chronic urticaria, Allergic conjunctivitis.
At a glance
| Generic name | Antihistamine Cetirizine Hydrochloride |
|---|---|
| Sponsor | Goldman, Butterwick, Fitzpatrick and Groff |
| Drug class | H1-receptor antagonist (second-generation antihistamine) |
| Target | H1 histamine receptor |
| Modality | Small molecule |
| Therapeutic area | Immunology / Allergy |
| Phase | FDA-approved |
Mechanism of action
Cetirizine is a selective H1-receptor antagonist that crosses the blood-brain barrier minimally, reducing central nervous system effects compared to first-generation antihistamines. By competitively blocking histamine binding to H1 receptors on mast cells, basophils, and other immune cells, it suppresses the release and effects of histamine, thereby alleviating allergic symptoms such as itching, urticaria, and rhinitis.
Approved indications
- Allergic rhinitis (seasonal and perennial)
- Chronic urticaria
- Allergic conjunctivitis
- Allergic asthma
Common side effects
- Somnolence
- Headache
- Fatigue
- Dry mouth
- Pharyngitis
Key clinical trials
- Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC) (PHASE2)
- A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Negative, Chronic Hepatitis B Virus (HBV) Infection (PHASE2)
- Extension Study of the Safety and Efficacy of Multi-dose Intravenous ARC-520 in Patients With Chronic Hepatitis B (HBV) Infection (PHASE2)
- Study of ARC-520 With or Without Other Drugs Used in the Treatment of Chronic Chronic Hepatitis B Virus (HBV) (PHASE2)
- A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Positive, Chronic Hepatitis B Virus Infection (PHASE2)
- Comparing Standard-Dose and High-Dose Cetirizine for Acute Urticaria (NA)
- Study of H3B-6545 in Japanese Women With Estrogen Receptor (ER)-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer (PHASE1)
- Efficacy of Antihistamine Drugs as Medical Expulsive Therapy Alone or in Combination With Alpha Blockers: A Prospective Randomized Controlled Study (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Antihistamine Cetirizine Hydrochloride CI brief — competitive landscape report
- Antihistamine Cetirizine Hydrochloride updates RSS · CI watch RSS
- Goldman, Butterwick, Fitzpatrick and Groff portfolio CI
Frequently asked questions about Antihistamine Cetirizine Hydrochloride
What is Antihistamine Cetirizine Hydrochloride?
How does Antihistamine Cetirizine Hydrochloride work?
What is Antihistamine Cetirizine Hydrochloride used for?
Who makes Antihistamine Cetirizine Hydrochloride?
What drug class is Antihistamine Cetirizine Hydrochloride in?
What development phase is Antihistamine Cetirizine Hydrochloride in?
What are the side effects of Antihistamine Cetirizine Hydrochloride?
What does Antihistamine Cetirizine Hydrochloride target?
Related
- Drug class: All H1-receptor antagonist (second-generation antihistamine) drugs
- Target: All drugs targeting H1 histamine receptor
- Manufacturer: Goldman, Butterwick, Fitzpatrick and Groff — full pipeline
- Therapeutic area: All drugs in Immunology / Allergy
- Indication: Drugs for Allergic rhinitis (seasonal and perennial)
- Indication: Drugs for Chronic urticaria
- Indication: Drugs for Allergic conjunctivitis
- Compare: Antihistamine Cetirizine Hydrochloride vs similar drugs
- Pricing: Antihistamine Cetirizine Hydrochloride cost, discount & access