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Antibody-Drug Conjugate
Antibody-drug conjugates target specific cancer cells by binding to a protein on the cell surface, delivering a toxic payload to kill the cell.
Antibody-drug conjugates target specific cancer cells by binding to a protein on the cell surface, delivering a toxic payload to kill the cell. Used for Various types of cancer, including breast, lung, and ovarian cancer.
At a glance
| Generic name | Antibody-Drug Conjugate |
|---|---|
| Sponsor | Sung-Soo Park |
| Drug class | Antibody-drug conjugate |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
This mechanism involves the use of monoclonal antibodies that are engineered to bind to a specific protein on the surface of cancer cells. Once bound, the antibody is internalized by the cell, releasing a toxic payload that kills the cell. This approach allows for targeted therapy with reduced harm to healthy cells.
Approved indications
- Various types of cancer, including breast, lung, and ovarian cancer
Common side effects
- Neutropenia
- Fatigue
- Nausea
Key clinical trials
- A Phase 1 Study of IM-1021 in Participants With Advanced Cancer (PHASE1)
- Brentuximab Vedotin and Nivolumab With or Without Ipilimumab in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma (PHASE1, PHASE2)
- Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia (PHASE2)
- A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011) (PHASE3)
- Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors (PHASE1)
- Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer (PHASE2)
- Brentuximab Vedotin and Combination Chemotherapy in Treating Children and Young Adults With Stage IIB, Stage IIIB, IVA, or IVB Hodgkin Lymphoma (PHASE3)
- Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Antibody-Drug Conjugate CI brief — competitive landscape report
- Antibody-Drug Conjugate updates RSS · CI watch RSS
- Sung-Soo Park portfolio CI