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antibiotic prophylaxis
Antibiotic prophylaxis prevents surgical site infections by eliminating bacteria before they can establish infection at the surgical wound.
Antibiotic prophylaxis prevents surgical site infections by eliminating bacteria before they can establish infection at the surgical wound. Used for Surgical site infection prophylaxis in gynecologic oncology procedures.
At a glance
| Generic name | antibiotic prophylaxis |
|---|---|
| Also known as | Rocephin (ceftriaxone) |
| Sponsor | The Central and Eastern European Gynecologic Oncology Group |
| Drug class | Antibiotic (prophylactic) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease Prevention / Surgical Prophylaxis |
| Phase | FDA-approved |
Mechanism of action
Prophylactic antibiotics are administered perioperatively to reduce the bacterial load and prevent pathogenic colonization of the surgical site. This is a standard preventive measure in gynecologic oncology procedures to minimize postoperative infectious complications. The specific antibiotic choice depends on the procedure type and local resistance patterns.
Approved indications
- Surgical site infection prophylaxis in gynecologic oncology procedures
Common side effects
- Allergic reaction
- Gastrointestinal disturbance
- Clostridium difficile infection
Key clinical trials
- Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery (PHASE4)
- Enhanced Recovery After Surgery (ERAS) in Patients With Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery With or Without HIPEC (NA)
- Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study (PHASE4)
- metaCARpal Bone Osteosynthesis Trail (NA)
- Feasibility Study of Ocular Surface Squamous Neoplasia Surgical Excision in People Living With HIV in Sub-Saharan Africa (NA)
- SHAPE Pilot Trial: Skin Health and Allergy Prevention Exposure (NA)
- Integrating Point of Care Testing (POCT) For Newborn Screening and Early Care for Sickle Cell Disease in Yopougon, Côte d'Ivoire (PHASE4)
- Doxycycline for the Prevention of Spontaneous Bacterial Peritonitis
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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