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Antibiotic coated intramedullary Nail
An intramedullary nail coated with antibiotics that provides structural support for bone fractures while locally delivering antimicrobial agents to prevent infection at the surgical site.
An intramedullary nail coated with antibiotics that provides structural support for bone fractures while locally delivering antimicrobial agents to prevent infection at the surgical site. Used for Fracture fixation with infection prevention (long bone fractures amenable to intramedullary nailing).
At a glance
| Generic name | Antibiotic coated intramedullary Nail |
|---|---|
| Also known as | Local Gentamicin 560 Powder, Vancomycin 2gm Liquid |
| Sponsor | Wake Forest University Health Sciences |
| Modality | Small molecule |
| Therapeutic area | Orthopedic Surgery / Trauma |
| Phase | FDA-approved |
Mechanism of action
This is a medical device—specifically an orthopedic implant used to stabilize and align fractured bones during healing. The antibiotic coating (typically including agents like rifampin or other broad-spectrum antibiotics) is released locally around the implant to reduce the risk of surgical site infections and osteomyelitis, which are common complications of intramedullary nailing procedures.
Approved indications
- Fracture fixation with infection prevention (long bone fractures amenable to intramedullary nailing)
Common side effects
- Surgical site infection
- Osteomyelitis
- Device-related complications (migration, breakage)
Key clinical trials
- Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial (PHASE4)
- Intramedullary Nailing vs External Ring Fixation for the Treatment of Tibial Shaft Fractures (NA)
- Articulating Versus Static Antibiotic Loaded Spacers for the Treatment of Prosthetic Knee Infection (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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