Last reviewed · How we verify
Antibiotic Cement Bead Pouch
An antibiotic-impregnated cement bead pouch that delivers high local concentrations of antibiotics directly to surgical sites to prevent or treat bone and soft tissue infections.
An antibiotic-impregnated cement bead pouch that delivers high local concentrations of antibiotics directly to surgical sites to prevent or treat bone and soft tissue infections. Used for Prevention and treatment of surgical site infections in orthopedic procedures, Bone and soft tissue infections following trauma or surgical intervention.
At a glance
| Generic name | Antibiotic Cement Bead Pouch |
|---|---|
| Sponsor | University of Maryland, Baltimore |
| Drug class | Antibiotic-eluting device |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Orthopedic Surgery |
| Phase | Phase 3 |
Mechanism of action
The device consists of polymethylmethacrylate (PMMA) cement beads loaded with antibiotics (typically vancomycin and/or gentamicin) contained within a dissolvable pouch. When placed at the surgical site, the beads elute antibiotics locally over time, achieving bactericidal concentrations while minimizing systemic exposure. The pouch allows for easy placement and removal while the beads provide sustained antimicrobial activity at the infection site.
Approved indications
- Prevention and treatment of surgical site infections in orthopedic procedures
- Bone and soft tissue infections following trauma or surgical intervention
Common side effects
- Local inflammatory response
- Allergic reaction to antibiotic components
- Device-related complications (migration, retention)
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |