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Antiarrhythmic Drugs
Antiarrhythmic drugs work by modulating cardiac electrical conduction to restore and maintain normal heart rhythm.
Antiarrhythmic drugs work by modulating cardiac electrical conduction to restore and maintain normal heart rhythm. Used for Atrial fibrillation, Ventricular arrhythmias, Supraventricular tachycardia.
At a glance
| Generic name | Antiarrhythmic Drugs |
|---|---|
| Also known as | amiodarone |
| Sponsor | Medtronic Cardiac Ablation Solutions |
| Drug class | Antiarrhythmic agents (Class I, II, III, or IV) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Antiarrhythmics act through various mechanisms including sodium channel blockade (Class I), beta-adrenergic antagonism (Class II), potassium channel blockade/repolarization prolongation (Class III), and calcium channel antagonism (Class IV). By altering the electrophysiological properties of cardiac tissue, these agents suppress abnormal electrical activity and prevent arrhythmia initiation and propagation. Medtronic's cardiac ablation solutions typically integrate antiarrhythmic therapy with catheter-based ablation procedures to treat arrhythmias.
Approved indications
- Atrial fibrillation
- Ventricular arrhythmias
- Supraventricular tachycardia
- Arrhythmia prevention post-ablation
Common side effects
- Bradycardia
- Hypotension
- Dizziness
- Proarrhythmic effects
- Fatigue
- Nausea
Key clinical trials
- Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies (NA)
- The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients (PHASE4)
- Acupuncture for Preventing Atrial Arrhythmia Recurrence After Ablation (NA)
- Catheter Ablation Versus Anti-arrhythmic Drugs for Ventricular Tachycardia (NA)
- Role of Combination Therapy of Glucose Insulin Potassium Infusion (GIK), Intravenous Hydrocortisone and Oral Sevelamer in Treatment of Acute Aluminum Phosphide Poisoned Cases Admitted to Intensive Care Unit (ICU) at Sohag University Hospitals. (NA)
- Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance (PHASE4)
- Efficacy of Early Rhythm Control Therapy in Patients With Subclinical Atrial Fibrillation (NA)
- Catheter Ablation Versus Anti-arrhythmic Drugs for Premature Ventricular Complexes (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Antiarrhythmic Drugs CI brief — competitive landscape report
- Antiarrhythmic Drugs updates RSS · CI watch RSS
- Medtronic Cardiac Ablation Solutions portfolio CI