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Anti-PD-1 monoclonal antibody
Anti-PD-1 monoclonal antibody is a PD-1 inhibitor Small molecule drug developed by Yancheng First People's Hospital. It is currently in Phase 3 development for Advanced or metastatic cancers (specific indications under investigation in phase 3). Also known as: PD-1 inhibitors, Tyvyt, Anti-PD-1, PD-1 inhibitor.
This drug blocks the PD-1 checkpoint protein on immune cells, allowing them to recognize and attack cancer cells.
This drug blocks the PD-1 checkpoint protein on immune cells, allowing them to recognize and attack cancer cells. Used for Advanced or metastatic cancers (specific indications under investigation in phase 3).
At a glance
| Generic name | Anti-PD-1 monoclonal antibody |
|---|---|
| Also known as | PD-1 inhibitors, Tyvyt, Anti-PD-1, PD-1 inhibitor, Camrelizumab |
| Sponsor | Yancheng First People's Hospital |
| Drug class | PD-1 inhibitor |
| Target | PD-1 |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
PD-1 is an inhibitory receptor on T cells that cancer cells exploit to evade immune detection by engaging its ligands (PD-L1/PD-L2). By binding to and blocking PD-1, this monoclonal antibody prevents this immune evasion, restoring T cell activation, proliferation, and anti-tumor cytotoxicity. This mechanism is effective across multiple cancer types that express PD-L1.
Approved indications
- Advanced or metastatic cancers (specific indications under investigation in phase 3)
Common side effects
- Fatigue
- Immune-related pneumonitis
- Immune-related colitis
- Immune-related hepatitis
- Rash
- Hypothyroidism
Key clinical trials
- BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia (PHASE1)
- Nivolumab and Ipilimumab in Treating Patients With Rare Tumors (PHASE2)
- Testing the Combination of ZEN003694 and Nivolumab With or Without Ipilimumab in Solid Tumors (PHASE1)
- A Study of Fianlimab, Cemiplimab, and Ipilimumab in People With Melanoma (PHASE2)
- Testing the Combination of Anetumab Ravtansine With Either Nivolumab, Nivolumab and Ipilimumab, or Gemcitabine and Nivolumab in Advanced Pancreatic Cancer (PHASE1)
- Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors (PHASE1, PHASE2)
- Testing the Combination of Anti-cancer Drugs Actimab-A and Cemiplimab (REGN2810) to Improve Outcomes for Patients With Recurrent Glioblastoma (PHASE1)
- Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Anti-PD-1 monoclonal antibody CI brief — competitive landscape report
- Anti-PD-1 monoclonal antibody updates RSS · CI watch RSS
- Yancheng First People's Hospital portfolio CI
Frequently asked questions about Anti-PD-1 monoclonal antibody
What is Anti-PD-1 monoclonal antibody?
How does Anti-PD-1 monoclonal antibody work?
What is Anti-PD-1 monoclonal antibody used for?
Who makes Anti-PD-1 monoclonal antibody?
Is Anti-PD-1 monoclonal antibody also known as anything else?
What drug class is Anti-PD-1 monoclonal antibody in?
What development phase is Anti-PD-1 monoclonal antibody in?
What are the side effects of Anti-PD-1 monoclonal antibody?
What does Anti-PD-1 monoclonal antibody target?
Related
- Drug class: All PD-1 inhibitor drugs
- Target: All drugs targeting PD-1
- Manufacturer: Yancheng First People's Hospital — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Advanced or metastatic cancers (specific indications under investigation in phase 3)
- Also known as: PD-1 inhibitors, Tyvyt, Anti-PD-1, PD-1 inhibitor, Camrelizumab
- Compare: Anti-PD-1 monoclonal antibody vs similar drugs
- Pricing: Anti-PD-1 monoclonal antibody cost, discount & access