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Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine
Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine is a Combination chemotherapy regimen Small molecule drug developed by National Cancer Center, Korea. It is currently in Phase 3 development for Breast cancer (likely indication based on typical use of this combination). Also known as: Taxotere, Xeloda, Cytoxan, doxorubicin.
This is a combination chemotherapy regimen that uses multiple agents to damage cancer cell DNA and disrupt cell division through different mechanisms.
This is a combination chemotherapy regimen that uses multiple agents to damage cancer cell DNA and disrupt cell division through different mechanisms. Used for Breast cancer (likely indication based on typical use of this combination).
At a glance
| Generic name | Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine |
|---|---|
| Also known as | Taxotere, Xeloda, Cytoxan, doxorubicin |
| Sponsor | National Cancer Center, Korea |
| Drug class | Combination chemotherapy regimen |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Anthracyclines intercalate into DNA and generate reactive oxygen species to kill rapidly dividing cells. Cyclophosphamide is an alkylating agent that cross-links DNA strands. Docetaxel stabilizes microtubules to prevent mitotic spindle formation. Capecitabine is a fluoropyrimidine that inhibits thymidylate synthase and gets incorporated into DNA/RNA. Together, these agents provide synergistic cytotoxic effects against cancer cells.
Approved indications
- Breast cancer (likely indication based on typical use of this combination)
Common side effects
- Neutropenia
- Anemia
- Thrombocytopenia
- Nausea and vomiting
- Mucositis
- Cardiotoxicity (anthracycline-related)
- Peripheral neuropathy (docetaxel-related)
- Hand-foot syndrome (capecitabine-related)
Key clinical trials
- Trial Studying Chemotherapy in Nigerian Women With Triple Negative Breast Cancer (PHASE2)
- TAC Versus TCX as Adjuvant Treatment for High-risk Her2-Negative Breast Cancer (PHASE3)
- SAFIR02_Breast - Efficacy of Genome Analysis as a Therapeutic Decision Tool for Patients With Metastatic Breast Cancer (PHASE2)
- Biomarkers in Women Receiving Chemotherapy & Celecoxib for Stage II or Stage III Breast Cancer Removable by Surgery (PHASE2)
- EC Followed Docetaxel Versus ET Followed Capecitabine as Adjuvant Chemotherapy for Node Positive Operable Breast Cancer (PHASE3)
- Trial of Neoadjuvant Docetaxel ± Metronomic Capecitabine/CTX Followed by FEC in Women With Operable Triple Negative Breast Cancer (PHASE2)
- Neoadjuvant Treatment of Breast Cancer
- Therapy With Bevacizumab (BEV), Doxorubicin, and Cyclophosphamide Followed by BEV, Docetaxel, and Capecitabine Before Surgery Followed by BEV Alone After Surgery for Women With Locally Advanced Breast Cancer (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine CI brief — competitive landscape report
- Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine updates RSS · CI watch RSS
- National Cancer Center, Korea portfolio CI
Frequently asked questions about Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine
What is Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine?
How does Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine work?
What is Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine used for?
Who makes Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine?
Is Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine also known as anything else?
What drug class is Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine in?
What development phase is Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine in?
What are the side effects of Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine?
Related
- Drug class: All Combination chemotherapy regimen drugs
- Manufacturer: National Cancer Center, Korea — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Breast cancer (likely indication based on typical use of this combination)
- Also known as: Taxotere, Xeloda, Cytoxan, doxorubicin
- Compare: Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine vs similar drugs
- Pricing: Anthracycline, Cyclophosphamide, Docetaxel, Capecitabine cost, discount & access