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Anesthesia (Lidocaine 15%)
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Topical local anesthesia for minor surgical procedures and pain relief.
At a glance
| Generic name | Anesthesia (Lidocaine 15%) |
|---|---|
| Also known as | Nummit |
| Sponsor | Lumbini Medical College |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through sodium-selective channels in the nerve cell membrane, thereby preventing depolarization and blocking the generation and propagation of action potentials. At a 15% concentration, it is formulated for topical application to provide rapid onset of anesthesia at the site of application. This mechanism allows it to numb tissue locally without systemic effects when applied appropriately.
Approved indications
- Topical local anesthesia for minor surgical procedures and pain relief
Common side effects
- Allergic reactions (rare with amide lidocaine)
- Systemic toxicity (if absorbed in excess)
- Local irritation or burning at application site
- Methemoglobinemia (rare, with high doses)
Key clinical trials
- Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial (NA)
- Intraoperative Nebulization of Lidocaine and Postoperative Pulmonary Complications (PHASE3)
- Effect of Bilateral Rhomboid Intercostal Block on Postoperative Pain After Breast Implant Surgery (NA)
- Transdiscal vs Paravertebral Neurolytic Splanchnic Nerve Block for Upper Abdominal Cancer Pain (NA)
- Comparison of Post-Dural Puncture Headache After Spinal Anesthesia Using Median Versus Paramedian Approach (NA)
- Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Split Mouth Randomized Study (NA)
- Comparison of SPSIP Block and SAP Block in Non-Intubated Uniportal VATS. (NA)
- Low-Cost Platelet-Rich Plasma for Hemarthropathy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Anesthesia (Lidocaine 15%) CI brief — competitive landscape report
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- Lumbini Medical College portfolio CI