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An epidural blood patch (EBP)
An epidural blood patch seals a dural puncture by injecting autologous blood into the epidural space to restore cerebrospinal fluid pressure and stop leakage.
An epidural blood patch seals a dural puncture by injecting autologous blood into the epidural space to restore cerebrospinal fluid pressure and stop leakage. Used for Post-dural puncture headache (PDPH) refractory to conservative management, Cerebrospinal fluid leakage following spinal anesthesia or lumbar puncture.
At a glance
| Generic name | An epidural blood patch (EBP) |
|---|---|
| Sponsor | Al-Azhar University |
| Modality | Biologic |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
EBP is a procedural intervention used to treat post-dural puncture headache (PDPH) caused by cerebrospinal fluid (CSF) leakage through a dural tear. Autologous blood is injected into the epidural space near the puncture site, where it forms a clot that seals the dural defect and restores normal CSF pressure, thereby alleviating headache and associated symptoms. The mechanism is both mechanical (sealing the hole) and biochemical (promoting local hemostasis and tissue healing).
Approved indications
- Post-dural puncture headache (PDPH) refractory to conservative management
- Cerebrospinal fluid leakage following spinal anesthesia or lumbar puncture
Common side effects
- Back pain
- Transient neurological symptoms
- Headache recurrence
- Infection at injection site
Key clinical trials
- Pregabalin in Treatment of Postdural Puncture Headache (PHASE3)
- Therapeutic Epidural Patch Versus Pain Block in the Midface for Headache (PHASE3)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |