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Amlodipine plus Hydrochlorothiazide
Amlodipine relaxes blood vessels by blocking calcium channels, while hydrochlorothiazide reduces blood volume by increasing sodium and water excretion through the kidneys, together lowering blood pressure.
Amlodipine relaxes blood vessels by blocking calcium channels, while hydrochlorothiazide reduces blood volume by increasing sodium and water excretion through the kidneys, together lowering blood pressure. Used for Hypertension.
At a glance
| Generic name | Amlodipine plus Hydrochlorothiazide |
|---|---|
| Sponsor | University of Abuja |
| Drug class | Calcium channel blocker + thiazide diuretic combination |
| Target | L-type voltage-gated calcium channel (amlodipine); sodium-chloride cotransporter (hydrochlorothiazide) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Amlodipine is a dihydropyridine calcium channel blocker that inhibits L-type calcium channels in vascular smooth muscle, causing vasodilation and reduced peripheral resistance. Hydrochlorothiazide is a thiazide diuretic that inhibits the sodium-chloride cotransporter in the distal convoluted tubule, promoting natriuresis and reducing circulating blood volume. The combination provides complementary antihypertensive effects through different mechanisms.
Approved indications
- Hypertension
Common side effects
- Peripheral edema
- Headache
- Dizziness
- Hypokalemia
- Hyperglycemia
- Flushing
- Fatigue
Key clinical trials
- Triple Antihypertensive Medication After Intracerebral Hemorrhage for Blood Pressure Control (NA)
- Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension (PHASE4)
- Integration of Hypertension Management in HIV Care in Uganda (NA)
- INTERVENCION Trial (PHASE4)
- Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT®️ for Systemic Arterial Hypertension (PHASE3)
- Standardized Antihypertensive Treatment Protocol (NA)
- Losartan and HCTZ and Amlodipine vs Atenolol and Amlodipine (0954A-309)(COMPLETED) (PHASE4)
- Integrating Hypertension Management in DSD for HIV
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Amlodipine plus Hydrochlorothiazide CI brief — competitive landscape report
- Amlodipine plus Hydrochlorothiazide updates RSS · CI watch RSS
- University of Abuja portfolio CI