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Aminophyllin
At a glance
| Generic name | Aminophyllin |
|---|---|
| Sponsor | University of Padova |
| Target | Adenosine receptor A3, Alkaline phosphatase, tissue-nonspecific isozyme, Adenosine receptor A1 |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | FDA-approved |
Approved indications
- Acute exacerbation of asthma
- Asthma
- Asthma management
- Asthma night-time symptoms
- Asthma-chronic obstructive pulmonary disease overlap syndrome
- Bronchitis
- Bronchospasm
- COPD Associated with Chronic Bronchitis
- Chronic Obstructive Pulmonary Disease with Bronchospasms
- Disorder of lung
- Pulmonary emphysema
Common side effects
- Nausea
- Vomiting
- Headache
- Insomnia
- Diarrhea
- Irritability
- Restlessness
- Fine skeletal muscle tremors
- Transient diuresis
Serious adverse events
- Cardiac arrhythmias
- Intractable seizures
- Persistent vomiting
- Multifocal atrial tachycardia
- Atrial flutter
- Seizures
- Severe allergic reactions/exfoliative dermatitis
- Ventricular arrhythmias with hemodynamic instability
- Hypotension/shock
- Death
Key clinical trials
- Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures (NA)
- A Study to Evaluate Efficacy, Safety, and Tolerability of Alemtuzumab in Pediatric Patients With RRMS With Disease Activity on Prior DMT (PHASE3)
- Prevention of Cisplatin-induced Nephrotoxicity (PHASE2, PHASE3)
- Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage (PHASE1, PHASE2)
- Heart Rhythm Changes in Patients With Atrial Fibrillation After Cardiopulmonary Bypass: a Retrospective Analysis
- Intra-ureteric Aminophylline Instillation on Flexible Ureteroscopy Procedure (NA)
- Timing of Aminophylline and Recovery in Pediatric Ambulatory Surgery (PHASE3)
- Reversal of Complete Heart Block With Aminophylline in Inferior Wall Myocardial Infarction Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Aminophyllin CI brief — competitive landscape report
- Aminophyllin updates RSS · CI watch RSS
- University of Padova portfolio CI