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American ginseng
American ginseng contains bioactive compounds (ginsenosides) that modulate immune function, reduce inflammation, and enhance stress resistance through multiple cellular pathways.
American ginseng contains bioactive compounds (ginsenosides) that modulate immune function, reduce inflammation, and enhance stress resistance through multiple cellular pathways. Used for Cancer-related fatigue, General fatigue and stress resistance, Immune support.
At a glance
| Generic name | American ginseng |
|---|---|
| Also known as | Efavienz (Sustiva), ginseng, Ginseng Root, Panax quinquifolius, Panax quinquefolius |
| Sponsor | Johns Hopkins University |
| Drug class | Herbal adaptogen |
| Modality | Small molecule |
| Therapeutic area | General wellness, fatigue, immunomodulation |
| Phase | FDA-approved |
Mechanism of action
American ginseng (Panax quinquefolius) contains ginsenosides and polysaccharides that act as adaptogens, helping the body resist physical and mental stress. These compounds interact with multiple targets including immune cells, cytokine pathways, and stress hormone regulation. The herb has been studied for immunomodulatory effects, antioxidant activity, and potential benefits in fatigue and cognitive function.
Approved indications
- Cancer-related fatigue
- General fatigue and stress resistance
- Immune support
Common side effects
- Insomnia
- Headache
- Gastrointestinal upset
- Nervousness
Key clinical trials
- Plant Protein With Ashwagandha-Rhodiola for Sleep Quality (NA)
- Assessing the Impact of Herbal Supplement on Fatigue and Disease Activity in SLE: Results From an 8-Week Randomized Trial (NA)
- Weak Pulse at Yang and Wiry Pulse at Yin Theory (NA)
- Multi-center Randomized Controlled Clinical Study of Shenling Baishu Granule to Prevent the Recurrence of Low-risk Colorectal Adenoma (PHASE4)
- A Study on the Improvement of Postoperative Symptoms and Survival Benefits of Modified Bufei Decoction in Elderly Patients With Lung Cancer Undergoing Radical Surgery (NA)
- Effect of Korean Red Ginseng on Oxidation in Middle-aged and Elderly Sub-health Population (PHASE2, PHASE3)
- Quantifiably Determine if the Botanical Formulation, LLP-01, Has a Significant Clinical Effect on Proteomic Inflammatory and Cardiovascular Biomarkers in Healthy, Older Individuals. (NA)
- Wisconsin Ginseng for Decreasing Cancer Related Fatigue (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- American ginseng CI brief — competitive landscape report
- American ginseng updates RSS · CI watch RSS
- Johns Hopkins University portfolio CI