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Alprostadil ﹠control
Alprostadil is a prostaglandin E1 analog that vasodilates blood vessels and inhibits platelet aggregation.
Alprostadil is a prostaglandin E1 analog that vasodilates blood vessels and inhibits platelet aggregation. Used for Peripheral arterial occlusive disease, Intermittent claudication, Erectile dysfunction.
At a glance
| Generic name | Alprostadil ﹠control |
|---|---|
| Also known as | Drug: Alprostadil, lipo-alprostadil, Prostaglandin E1, Drug: normal salin |
| Sponsor | Shanghai 10th People's Hospital |
| Drug class | Prostaglandin E1 analog |
| Target | Prostanoid receptors (EP receptors) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Alprostadil binds to prostanoid receptors on vascular smooth muscle and platelets, causing relaxation of vascular smooth muscle cells and increased blood flow. It also reduces platelet activation and aggregation, improving microcirculation and tissue perfusion. These effects make it useful in conditions characterized by poor blood flow and tissue ischemia.
Approved indications
- Peripheral arterial occlusive disease
- Intermittent claudication
- Erectile dysfunction
- Diabetic angiopathy
Common side effects
- Flushing
- Headache
- Dizziness
- Hypotension
- Tachycardia
- Injection site pain
Key clinical trials
- Technology-based Distraction Techniques in Managing Children With Attention-deficit/Hyperactivity Disorder (NA)
- Lubiprostone Combined With Maintenance Therapy for Prevention of Postoperative Recurrence in Peritoneal Metastatic Colorectal Cancer (PHASE2)
- Efficacy and Safety of Lubiprostone in the Treatment of Slow Transit Constipation (PHASE3)
- A Trial of Neurofeedback as an Adjunctive Treatment for Youth in Outpatient Mental Health Settings (NA)
- The Effect of a Music Intervention on Postictal Agitation in Electroconvulsive Therapy Patients (NA)
- An Intervention to Enhance Well-Being in Trauma Exposed New Mothers (NA)
- Cervical Ripening With Misoprostol vs Isosorbide Mononitrate ; A Parallel -Arm Randomized Controlled Trial (NA)
- The Effectiveness of Individualized Imagery Scripts on Sleep, Psychosis, and Suicidality Among Inpatients With Psychosis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Alprostadil ﹠control CI brief — competitive landscape report
- Alprostadil ﹠control updates RSS · CI watch RSS
- Shanghai 10th People's Hospital portfolio CI