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Alprostadil 20 micrograms
Alprostadil is a prostaglandin E1 analog that vasodilates blood vessels and inhibits platelet aggregation.
Alprostadil is a prostaglandin E1 analog that vasodilates blood vessels and inhibits platelet aggregation. Used for Peripheral arterial occlusive disease, Intermittent claudication, Critical limb ischemia.
At a glance
| Generic name | Alprostadil 20 micrograms |
|---|---|
| Sponsor | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia |
| Drug class | Prostaglandin E1 analog |
| Target | Prostanoid receptors (EP receptors) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 2 |
Mechanism of action
Alprostadil binds to prostanoid receptors on vascular smooth muscle and platelets, triggering increased intracellular cAMP levels. This leads to relaxation of vascular smooth muscle (vasodilation), improved blood flow, and reduced platelet clumping. These effects improve tissue perfusion and oxygenation in ischemic conditions.
Approved indications
- Peripheral arterial occlusive disease
- Intermittent claudication
- Critical limb ischemia
Common side effects
- Flushing
- Headache
- Hypotension
- Tachycardia
- Jaw pain
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