Last reviewed 2026-04-22 · How we verify

AllerT

AllerT is an allergen immunotherapy that modulates immune tolerance to specific allergens through a peptide-based approach.

AllerT is an allergen immunotherapy that modulates immune tolerance to specific allergens through a peptide-based approach. Used for Allergic rhinitis and asthma (grass pollen allergy).

At a glance

Mechanism of action

AllerT uses synthetic peptides derived from major allergen epitopes to induce immune tolerance and reduce allergic responses. The therapy works by shifting the immune response away from IgE-mediated reactions toward regulatory T cell activation and IgG-blocking antibody production, thereby desensitizing patients to their specific allergens.

Approved indications

• Allergic rhinitis and asthma (grass pollen allergy)

Common side effects

• Local injection site reactions
• Mild systemic allergic reactions
• Itching or swelling at injection site

Key clinical trials

• ATIBAR - Efficacy and Safety of Two Doses of AllerT in Patients Allergic to Birch Pollen (PHASE2)
• Compare Dose Regimens of AllerT, in Adults With Allergic Rhino-Conjunctivitis to Birch Pollen Studied in EEC (PHASE2)
• Follow-up of Study AN004T to Assess the Persistence of AllerT Efficacy During the 2nd to 4th Season After Treatment
• Efficacy Study of a Preseasonal Treatment With AllerT in Subjects With Birch Pollen Allergy (PHASE2)
• Phase I/IIa Clinical Evaluation of AllerT vs Placebo in Subjects Allergic to Birch Pollen (PHASE1, PHASE2)
• Skin Prick Tests With AllerT in Subjects Allergic to Birch Pollen (PHASE1)

Primary sources

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