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albumin interferon alfa-2b
Albumin interferon alfa-2b is a recombinant form of interferon alfa-2b fused to human albumin, which is used to enhance its half-life and therapeutic effects.
Albumin interferon alfa-2b is a recombinant form of interferon alfa-2b fused to human albumin, which is used to enhance its half-life and therapeutic effects. Used for Hepatitis B.
At a glance
| Generic name | albumin interferon alfa-2b |
|---|---|
| Sponsor | Human Genome Sciences Inc. |
| Drug class | Interferon |
| Target | IFNAR |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Interferon alfa-2b is a cytokine that plays a key role in the body's immune response, particularly in the activation of immune cells and the production of antiviral proteins. By fusing it to albumin, the half-life of interferon alfa-2b is increased, allowing for more sustained therapeutic effects.
Approved indications
- Hepatitis B
Common side effects
- Flu-like symptoms
- Fatigue
- Headache
Key clinical trials
- Study of Recombinant Human Serum Albumin/Interferon alpha2b Fusion Protein in Hepatitis B Patient (PHASE1, PHASE2)
- Study of Recombinant Human Serum Albumin/Interferon alpha2b Fusion Protein in Chinese Healthy Volunteers (PHASE1)
- Safety and Efficacy of Albumin Interferon Administered Every 4 Weeks in Genotype 2/3 Hepatitis C Patients (PHASE2)
- Efficacy of Albumin Interferon Alfa-2b With Ribavirin Compared With Peg-IFN Alfa-2a With Ribavirin in IFN Naive Patients (PHASE3)
- Efficacy of Albumin Interferon Alfa-2b With Ribavirin Compared to Peg-IFN Alfa-2a With Ribavirin in IFN Naive Patients Geno2/3 (PHASE3)
- Cisplatin, Temozolomide, Abraxane, With Interleukin-2 and Interferon for Metastatic Melanoma (PHASE1)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |