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AeroLEF
AeroLEF is a liposome-encapsulated formulation of budesonide, a corticosteroid that reduces inflammation.
AeroLEF is a liposome-encapsulated formulation of budesonide, a corticosteroid that reduces inflammation. Used for Treatment of acute asthma exacerbations.
At a glance
| Generic name | AeroLEF |
|---|---|
| Also known as | Liposome-Encapsulated Fentanyl |
| Sponsor | YM BioSciences |
| Drug class | Corticosteroid |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | Phase 2 |
Mechanism of action
The liposome-encapsulated formulation of AeroLEF allows for targeted delivery of budesonide to the lungs, reducing systemic side effects and increasing local efficacy. This targeted delivery enables AeroLEF to effectively reduce inflammation in the lungs, making it a potential treatment for various respiratory conditions.
Approved indications
- Treatment of acute asthma exacerbations
Common side effects
- Headache
Key clinical trials
- Study Evaluating Inhaled AeroLEF Delivered in 4 Aerosol Delivery Devices in Healthy Volunteers (PHASE1)
- Phase II Study of Inhaled AeroLEF for Analgesia After ACL Knee Surgery (PHASE2)
- Study of Single and Multiple Doses of Inhaled AeroLEF (Liposome-Encapsulated Fentanyl)in Healthy Subjects (PHASE1)
- Study Evaluating Inhaled AeroLEF (Liposome-Encapsulated Fentanyl)in Normal Healthy Subjects (PHASE1)
- Study to Determine Efficacy and Safety of Inhaled AeroLEF in the Treatment of Acute Post-op Pain in Adult Patients Undergoing Elective Orthopedic Surgery (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- AeroLEF CI brief — competitive landscape report
- AeroLEF updates RSS · CI watch RSS
- YM BioSciences portfolio CI